Case Control Study: Determinants of Osteoporosis in GOLD II COPD Patients.

Determination of Risk Factors for Developing Osteoporosis in COPD GOLD II Patients. A Case Control Study to Identify Possible Risk Factors for Developing Osteoporosis in COPD GOLD II Patients.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00725673

Enrollment

106

Registered

2008-07-30

Start date

2007-09-30

Completion date

2009-06-30

Last updated

2009-11-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease, Osteoporosis

Keywords

COPD, Osteoporosis, BMD, DEXA-scan

Brief summary

Patients with COPD have been found to have an increased risk of osteoporosis. The underlying mechanism is not clear yet. This case control study aims to identify risk factors for osteoporosis in GOLD II COPD patients. COPD GOLD II patients with osteoporosis (cases) will be matched by gender and age to COPD GOLD II patients without osteoporosis(controls). Possible risk factors for osteoporosis are: * BMI/VVMI (body composition) * emphysema vs chronic bronchitis * physical capacity * Use of certain medication (eg corticosteroids, SSRI's) * Nutritional status * Infectious parameters Outpatients from the pulmonary ward of the Catharina Hospital Eindhoven with GOLD II COPD according to the ATS and GOLD-guidelines will be included in the study (after written informed consent). A DEXA-scan will be made, if patients are osteoporotic or have a normal BMD they will be included in the study. A HRCT will be made, a six minutes walking distance will be performed, blood will be drawn for lab. analysis, an X-ray of the vertebral collum will be made, impedance will be measured and hight and weight will be measuered. Also patients will fill in a questionaire. By univariate and multivariate analysis the collected data will be analysed to determine possible risk factors for th development of osteoporosis in COPD GOLD II patients.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \>= 40 years * GOLD II COPD * Written permission

Exclusion criteria

* Age \< 40 years * No COPD or COPD GOLD I, III or IV * no written permission

Design outcomes

Primary

Measure	Time frame
Risk factors for osteoporosis in GOLD II COPD patients	1 year

Countries

Netherlands

Outcome results