Postoperative Pain
Conditions
Keywords
NSAIDs, Postoperative pain, Analgesia, Abortion
Brief summary
Uterine contraction pain is a common problem after abortion. Optimal analgesic for such suffering is still needed to be guaranteed. Flurbiprofen Axetil is a target-distributable non-steroidal anti-inflammatory drug (NSAID) functioning via block the synthesis of prostaglandin E (PGE). The investigators hypothesized that Flurbiprofen Axetil could suppress the uterine contraction pain after abortion effectively.
Interventions
DRUGSaline
Saline 5 ml injection 10 min prior to propofol administration.
Flurbiprofen Axetil 50 mg in 5 ml injection 10min prior to propofol administration.
Sponsors
Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
19 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* ASA status I-II * Performing abortion operation (medical- or drug-induced * Requiring painless abortion
Exclusion criteria
* \< 19yrs, and \>= 45yrs * History of central active drugs administration * Drug abuse * Hypertension * Diabetes * Any other chronic diseases * Allergy to the study drugs * Habit of over-volume alcohol drinking * Records of history of centrally active drug use and psychiatry * Any organic disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS pain scorings | At the end of the operation, 0,5,15,30,60min after operation |
Secondary
| Measure | Time frame |
|---|---|
| Anesthetic consumptions | At the end of the operation |
| Overall VAS satisfaction scorings with analgesia | At the end of the study |
| Side effects | During the whole period of the study |
| Volume of bleeding | At the end of the study |
Countries
China
Outcome results
None listed