Hemodialysis
Conditions
Keywords
dialysate, sodium, hemodialysis, blood pressure, thirst, intradialytic symptoms, interdialytic weight gain, extracellular fluid balance, mechanisms
Brief summary
Patients currently receiving hemodialysis will be randomized to receive 1 of 3 dialysate sodium prescriptions. The effects on blood pressure, interdialytic weight gain, thirst, and intradialytic symptoms will be assessed.
Interventions
OTHERLowering the dialysate sodium
Please see above
Sponsors
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients on 3 times weekly hemodialysis of at least 3 months * elevated average ambulatory blood pressures * current dialysate sodium prescription 140mEq/L * average pre-dialysis serum sodium \<140mEq/L
Exclusion criteria
* frequent intradialytic hypotension * estimated life expectancy \<1 year * non-adherence to dialysis prescription * pregnancy * inability or unwillingness to complete study measures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ambulatory blood pressure | 3 months | Ambulatory blood pressure to be taken over 24 hours at 4 week intervals throughout the study |
Secondary
| Measure | Time frame |
|---|---|
| thirst | 3 months |
| QOL Scores (KDQOL, mins to recovery) | 3 months |
| intradialytic hypotension rate, intradialytic symptoms | 3 months |
| mechanistic outcomes: interdialytic weight gain, extracellular fluid water, sodium ionic mass balance | 3 months |
Countries
Canada
Outcome results
None listed