Skip to content

Acute Stroke Program of Interventions Addressing Racial and Ethnic Disparities

Acute Stroke Program of Interventions Addressing Racial and Ethnic Disparities

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT00724555
Acronym
ASPIRE
Enrollment
2005
Registered
2008-07-29
Start date
2008-02-29
Completion date
2013-01-31
Last updated
2014-01-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Keywords

stroke, tissue plasminogen activator, tPA

Brief summary

The purpose of this study is to increase treatment of acute stroke with tissue plasminogen activator (tPA) across the District of Columbia. This study, however, will not evaluate tPA as an intervention.

Detailed description

There are a number of well-known barriers to receiving tissue plasminogen activator (tPA) including transit time to hospital, paramedic and provider training, tPA standing orders, and provider guidelines. Among underserved populations, limited stroke knowledge, socioculturally determined attitudes, and beliefs and myths held by community members may serve as additional barriers that hinder these populations from receiving tPA and acute stroke care. Targeted multilevel interventions designed to overcome specific barriers may significantly increase the number of individuals with stroke who are appropriately treated with intravenous tPA (IV tPA) in underserved communities. Identification of the specific components of healthcare interventions that are the most effective is critical to improve delivery of acute stroke therapy. The goal of this study is to learn more about public knowledge, attitudes, beliefs and perceptions regarding stroke and stroke treatment in order to identify sociocultural and environmental barriers to receiving tPA and acute stroke care in an underserved community. This study will also determine if implementation of a multilevel intervention program can significantly increase the number of people with ischemic stroke who are appropriately treated with IV tPA in a predominantly underserved community. In the study, researchers will evaluate the different levels of the intervention to determine which efforts are most effective.

Interventions

None listed

Sponsors

Medstar Health Research Institute
CollaboratorOTHER
Howard University
CollaboratorOTHER
George Washington University
CollaboratorOTHER
University of Michigan
CollaboratorOTHER
University of Wisconsin, Madison
CollaboratorOTHER
Johns Hopkins University
CollaboratorOTHER
University of Alabama at Birmingham
CollaboratorOTHER
MedStar Good Samaritan Hospital
CollaboratorUNKNOWN
Union Memorial Hospital
CollaboratorOTHER
Georgetown University
Lead SponsorOTHER

Study design

Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* diagnosis of acute ischemic stroke * over the age of 18

Exclusion criteria

\-

Design outcomes

Primary

MeasureTime frame
The proportion of people with ischemic stroke appropriately treated with IV tPA.4 years

Secondary

MeasureTime frame
Qualitative data collected from the community will identify baseline levels of knowledge, attitudes, and perceived and encountered barriers to acute stroke treatment.1 year

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 8, 2026