Insulin Resistance, Sleep, Sleep Deprivation, Type 2 Diabetes
Conditions
Keywords
short sleep duration, energy expenditure, insulin secretion, insulin action, lipid turnover, free fatty acids
Brief summary
The use of energy from food changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the amount of energy that people who have a relative with type 2 diabetes (parent, sibling, or grandparent) use to perform their daily activities. This study is being done to test the hypothesis that the daily use of energy in people who have a history of type 2 diabetes in their family will be different after they have slept short hours for 16 days in comparison to when they have slept longer hours for 16 days.
Detailed description
Study participants will complete two 16-day inpatient stays in the sleep laboratory of the University of Chicago Clinical Resource Center that will be scheduled at least 4 weeks apart. Bedtime duration will be set at 5.5 hours per night during one of these stays and at 8.5 hours per night during the other. No daytime naps will be allowed. Study participants will be served regular daily meals including breakfast, lunch, dinner, and a bedtime snack. On weekdays all participants will engage in simulated office work in the sleep laboratory. During the rest of the time participants will maintain their usual indoor and outdoor activities as much as possible within the limits of the University of Chicago campus. At the beginning of each inpatient stay, study participants will drink a glass of water containing harmless non-radioactive dense forms of oxygen and hydrogen, small amounts of which are found in natural water. Several urine samples will be collected before and after the participants drink the water and again 14 days later in order to measure the amount of energy that was used by them during this time. At the end of each stay participants will also undergo measurements of their body composition (lean tissue, bone and fat) and their metabolic rate at rest and after a standard meal, and will complete tests to determine how much insulin does their body produce in response to an intravenous glucose infusion and how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.
Interventions
OTHER5.5-hour bedtime
16 days with sleep allowed only during a 5.5-hour bedtime period at night
OTHER8.5-hour bedtime
16 days with sleep allowed only during a 8.5-hour bedtime period at night
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
University of Chicago
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* regular sleep habits * BMI 20 to 27 kg/m2 * at least one parent, sibling or grandparent with type 2 diabetes * must exercise regularly
Exclusion criteria
* active smoker * night or shift work * have highly variable sleep habits * have a hormonal disorder * have a sleep disorder * have an active medical problem * women only: use of birth control pills * women only: irregular menstrual periods or pregnancy * use of medications/compounds that can disrupt sleep
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total energy expenditure | during each bedtime intervention |
Secondary
| Measure | Time frame |
|---|---|
| Physical activity related energy expenditure | during each bedtime intervention |
| Total body insulin sensitivity | at the end of each bedtime intervention |
| First and second phase insulin secretion | at the end of each bedtime intervention |
| Endogenous glucose production | at the end of each bedtime intervention |
| Glycerol turnover and free fatty acid concentration | at the end of each bedtime intervention |
Countries
United States
Outcome results
None listed