Dental Caries
Conditions
Keywords
White spot lesion, Tooth remineralization, Fluoride varnishes
Brief summary
The study hypothesis is the difference in therapeutic effect of two varnish formulations (G1 = NaF, 2.26%F, G2 = NaF, 2.71% F + CaF2). These products are commercially available in the Brazilian and international market and they are used for dental caries as white spot lesions control.
Detailed description
The aim of this study was to evaluate the therapeutic effect of two varnish formulations (G1 = NaF, 2.26%F, G2 = NaF, 2.71% F + CaF2) on the remineralization of white spot lesions (WSL). The sample was composed of 15 (7- to 12-year-old) children with 45 active WSL in anterior permanent teeth. The children were randomly divided in two groups providing 22 lesions for G1 and 23 for G2. The children were submitted to weekly varnish applications 4 times. The WSL were evaluated twice: baseline and on week 4. Maximum lesion dimensions (mesial-distal and incisal-gingival) were measured in millimeters and classified in four grades of size. WSL were also recorded assessing lesion activity by one calibrated examiner. The Pearson chi-square and Fisher's exact tests were used (P \< 0.01). WSL reductions were observed in both varnish groups (Chi-square= 0.15, d.f.=1, P=0.90); and with similar magnitude (in mm): 1.19 and 1.29 for G1 and G2, respectively. Thirty-six WLS (15 in G1 and 26 in G2) were classified as inactive in week 4 reaching an overall value of 80%. No difference was observed between G1 and G2 regarding activity scores (Fisher's exact test, p \> 0.01). It can be concluded that after 4 applications the two varnish formulations tested produced similar clinical effects indicating the reduction and the control of carious activity in most WSL.
Interventions
DRUGsodium fluoride
sodium fluoride 5%
DRUGsodium fluoride calcium fluoride
sodium fluoride 5% + calcium fluoride
Sponsors
University of Pernambuco
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
7 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* regular hygiene habits (brushing teeth everyday) * registered in public schools
Exclusion criteria
* dental caries such as small cavities or restorations in the target teeth (permanent anterior teeth) * development enamel alterations (hypoplasia, fluorosis) or periodontal disease * children using orthodontic devices * under medical treatment * taking any kind of medicine * no informed consent form signed
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| reduction of the size of the caries lesion | 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Inactivation of carious lesions | 4 weeks |
Countries
Brazil
Outcome results
None listed