Atherosclerosis
Conditions
Keywords
Atherosclerosis, Atorvastatin, Therapeutic lifestyle change, CIMT, ABI, PWV
Brief summary
The purpose of this study is to determine whether atorvastatin, aggressive lifestyle intervention, and their interaction are effective in delaying the progress of pre-clinical atherosclerosis.
Detailed description
Primary prevention of atherosclerotic disease remains a big challenge. Currently, it is not clear how to treat those subjects with evidence of pre-clinical atherosclerosis but without obvious conventional risk factors. This randomized, placebo controlled, double blind study is to evaluate the effect of Atorvastatin 10 mg daily, therapeutic lifestyle change, and their combination, on the progression of CIMT in those with higher baseline CIMT value but are not belong to 'high risk' category, according to the conventional risk factors.
Interventions
DRUGAtorvastatin
atorvastatin 10mg/d
BEHAVIORALAggressive lifestyle intervention
aggressive lifestyle intervention
Sponsors
Peking University First Hospital
Ministry of Science and Technology of the People´s Republic of China
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* CIMT is not less than 0.9 mm * without Clinical diagnosis of atherosclerotic disease * without Diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The progress of CIMT | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| The progress of ABI | 2 years |
| The progress of PWV | 2 years |
| Occurrence of atherosclerotic disease | 2 years |
Countries
China
Contacts
Primary ContactJianping Li
Outcome results
None listed