Anesthesia
Conditions
Keywords
Sevoflurane induction, Premedication, laryngeal mask airway, Anesthesia, inhalation [E03.155.197.197]
Brief summary
The goal of this study was to investigate the effects of fentanyl-midazolam premedication during sevoflurane induction pertaining to time to loss of eyelash reflex (LER), time and conditions of insertion of proseal laryngeal mask airway (PLMA), as well as cardio-respiratory data. Participants' anxiety level was also evaluated.
Detailed description
Eighty adult patients undergoing minor surgery were randomized in a double-blind fashion. Each group received either a NaCL placebo (NaCl), or a premedication consisting of fentanyl 0,6 ug/kg and midazolam 9 ug/kg (FM), five minutes before tidal volume sevoflurane 8% induction with 6 L/min O2. Times to LER and LMA insertion were recorded. Adverse events were also noted. Systolic blood pressure (sBP), heart rate (HR), respiratory rate (RR) and tidal volume (Vt) were recorded at one-minute intervals. End-tidal sevoflurane (EtSevo) and end-tidal CO2 (EtCO2) were noted immediately following LMA insertion. Anxiety levels (0-10 verbal scale) were registered before and after premedication. Patients were contacted 24 hours postoperatively and were asked if they remembered the mask being applied to their face.
Interventions
A combination of fentanyl 0.6 ug/kg and midazolam 9 ug/kg, to which NaCl was added to obtain a volume of 2.5 mL (group FM) injected IV, 5 minutes prior inhalation induction of anesthesia with sevoflurane
DRUGNaCl
NaCl 0.9% 2.5 ml intravenous (IV), 5 minutes prior inhalation induction of anesthesia with sevoflurane.
Sponsors
Maisonneuve-Rosemont Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* ASA physical status I-II * Minor elective surgery * General anesthesia
Exclusion criteria
* Gastroesophageal reflux * Exhibited a body mass index \> 32 kg/m2 * Took sedative or opioid drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Impact of administering a combination of low doses of IV fentanyl and midazolam on time to loss of consciousness, and time of insertion of a laryngeal mask airway during sevoflurane induction. | 5 minutes after the premedication, each 30 seconds until the insertion of laryngeal mask airway |
Secondary
| Measure | Time frame |
|---|---|
| Participants' cardiorespiratory status | 5 minutes after the premedication, at each minutes for 10 minutes |
| Patients' anxiety level | Before and after premedication and 24 hrs post op |
| Adverses events | 5 minutes after the premedication until the end of laryngeal mask insertion |
| Satisfaction | 24 hrs post op |
Countries
Canada
Outcome results
None listed