Resveratrol in Healthy Adult Participants

Inclusion criteria

Criteria: * Healthy adult participants meeting the following criteria: * Limit cruciferous vegetables to no more than one serving each week for about 6 weeks * Limit resveratrol-containing foods (i.e., wine, peanuts, mulberries, grapes, cranberries, blueberries, and huckleberries) to no more than one serving each per day for about 6 weeks * No caffeine-containing food or beverages (e.g., coffee, colas, chocolate, or over-the-counter medications) or food items that have been reported to affect drug/carcinogen metabolizing enzymes (e.g., grapefruit, grapefruit juice, cruciferous vegetables, and food cooked over charcoal) beginning 72 hours before and until 8 hours after each set of CYP probe drug administration * Leukocytes \>= 3,000/uL * Absolute neutrophil count \>= 1,500/uL * Platelet count \>= 100,000/uL * Total bilirubin =\< 2.0 mg/dL * AST/ALT =\< 1.5 times upper limit of normal (ULN) * Creatinine =\< ULN * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * Must have a resting systolic blood pressure \>= 100 mm Hg at screening and prior to probe drug administration * Must not consume more than three drinks of alcohol per week on average * No prior invasive cancers (i.e., non-skin cancer) within the past 5 years * No history of allergic reactions to resveratrol-containing products or CYP probe drugs (e.g, caffeine, dextromethorphan, losartan, or buspirone) * No uncontrolled intercurrent illness including, but not limited to, any of the following: * Ongoing or active infection * Symptomatic congestive heart failure * Unstable angina pectoris * Cardiac arrhythmia * Psychiatric illness or social situation that would limit compliance with study requirements * No over-the-counter medications beginning 72 hours before and until 8 hours after each CYP probe drug administration * No participation in another clinical intervention trial within the past 3 months * No concurrent medications or supplements that are known CYP enzyme inducers or inhibitors * No concurrent herbal medicines, dietary supplements, or above-standard vitamins or minerals (a standard daily multivitamin or mineral supplement is acceptable) * Non-smoking, defined as not currently smoking or stopped smoking more than 1 year ago * Normal liver and renal function * Able and willing to adhere to the following dietary restrictions: * ECOG performance status (PS) 0-1 OR Karnofsky PS 70-100%