Asthma, Chronic Inflammatory Diseases
Conditions
Keywords
Severe asthma, exacerbation, predictive factors, Severe
Brief summary
Asthma is a chronic inflammatory disease, affecting up to 10 % of the general population in developed countries. Corticosteroids are necessary to control symptoms, but induce adverse events sometimes intolerable. In severe asthma, which represent 5 to 10% of global asthma, corticosteroids frequently fail to prevent severe exacerbations, leading to emergency care, hospitalization and sometimes death. The aim of this study is to identify predictive factors specific for exacerbation outcome which will lead to a minor increase in treatment in order to prevent exacerbations, while minimizing drug adverse effects.
Interventions
OTHERspirometry, and blood taken
each month during one year
Sponsors
Nantes University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
: * Male or female adults aged ≥ 18 years, who have signed an Inform Consent Form prior to initiation of any study-related procedure * Patients with severe asthma with at least 2 exacerbations during the last 12 months that necessitated oral cortico-therapy or increase in oral cortico-therapy
Exclusion criteria
: * Pregnant or nursing women * Patients with other chronic inflammatory lung disease * Current smoker or a smoking history of 10 pack years or more
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of predictive factors for exacerbation outcome in severe asthmatics. | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of predictive factors identified in the study, in order to prevent exacerbations. | — |
Countries
France
Outcome results
None listed