Insulin Resistance, Sleep, Sleep Deprivation, Type 2 Diabetes
Conditions
Keywords
short sleep duration, glucose clamp technique, insulin secretion, insulin action, lipid turnover, free fatty acids
Brief summary
The use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). This study is being done to test the hypothesis that the carbohydrate metabolism of people who have a history of type 2 diabetes in their family will be different after they have slept short hours for 10 days in comparison to when they have slept longer hours for 10 days.
Detailed description
Study participants will complete two 10-day inpatient stays in the sleep laboratory of the University of Chicago Clinical Resource Center scheduled at least 4 weeks apart. Bedtime duration will be set at 5 hours per night during one of these stays and 8.5 hours per night during the other. No daytime naps will be allowed. Study participants will be served regular daily meals including breakfast, lunch, dinner, and a bedtime snack. On weekdays all participants will engage in simulated office work while in the sleep laboratory. During the rest of the time participants will maintain their usual indoor and outdoor activities as much as possible within the limits of the University of Chicago campus. During the last two days of each inpatient stay in the laboratory, participants will undergo two different tests. The first test will determine how much insulin does their body produce in response to an intravenous glucose infusion lasting several hours. The second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.
Interventions
OTHER5-hour bedtime
10 days with sleep restricted only to a 5-hour bedtime period at night
OTHER8.5-hour bedtimes
10 days with sleep allowed only during a 8.5-hour period at night
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
University of Chicago
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* regular sleep habits * BMI 20 to 27 kg/m2 * at least one parent, sibling or grandparent with type 2 diabetes * no regular exercise habits
Exclusion criteria
* active smoker * night or shift work * have highly variable sleep habits * have a hormonal disorder * have a sleep disorder * have an active medical problem * women only: use of birth control pills * women only: irregular menstrual periods or pregnancy * use of medications/compounds that can disrupt sleep
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total body insulin sensitivity | at the end of each bedtime intervention |
Secondary
| Measure | Time frame |
|---|---|
| First and second phase insulin secretion | at the end of each bedtime intervention |
| Endogenous glucose production | at the end of each bedtime intervention |
| Glycerol turnover and free fatty acid concentrations | at the end of each bedtime intervention |
Countries
United States
Outcome results
None listed