Glucose Metabolism and Sleep in People With Family History of Type 2 Diabetes.

Sleep, Energy Metabolism and Diabetes Risk.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00720889

Enrollment

Registered

2008-07-23

Start date

2008-07-31

Completion date

2012-03-31

Last updated

2013-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insulin Resistance, Sleep, Type 2 Diabetes

Keywords

short sleep duration, glucose clamp technique, insulin secretion, insulin action, lipid turnover, free fatty acids

Brief summary

The use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). This study is being done to test the hypothesis that individual differences in habitual sleep duration may be related to differences in the carbohydrate metabolism of people who have a history of type 2 diabetes in their family.

Detailed description

On two consecutive inpatient days, the participants in this study will undergo two different tests. The first test will determine how much insulin can their body produce in response to an intravenous glucose infusion over a period of several hours. The second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

21 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* regular sleep habits * BMI 20 to 27 kg/m2 * at least one parent, sibling or grandparent with type 2 diabetes * no regular exercise habits

Exclusion criteria

* active smoker * night or shift work * have highly variable sleep habits * have a hormonal disorder * have a sleep disorder * have an active medical problem * women only: use of birth control pills * women only: irregular menstrual periods or pregnancy * use of medications/compounds that can disrupt sleep

Design outcomes

Primary

Measure	Time frame
Total body insulin sensitivity	at the end of a 4-hour hyperinsulinemic clamp

Secondary

Measure	Time frame
First and second phase insulin secretion	during a 3-hour hyperglycemic clamp
Endogenous glucose production	before and during a 4-hour hyperinsulinemic clamp
Glycerol turnover and free fatty acid concentration	before and during a 4-hour hyperinsulinemic clamp

Countries

United States

Outcome results