Coronary Calcification, Vascular Calcification
Conditions
Keywords
coronary calcification, vascular calcification, sodium thiosulfate
Brief summary
The present study will examine the treatment effect of sodium thiosulfate on coronary calcification in patients on hemodialysis.
Detailed description
Coronary calcification (CAC) is prevalent among patients with end-stage renal disease (ESRD). High serum phosphate, the intake of calcium containing phosphate binder as well as dialysis vintage have been shown to be associated with the increasing prevalence of CAC. High CAC score examined by electron-beam CT scan or multi-slice CT scan associates with an increased cardiovascular mortality in ESRD. In series of case reports, intravenous sodium thiosulfate (STS) reduced the calcium burden in calcific uremic arteriopathy and soft tissue calcification. This was believed to be due to the calcium chelation effect of STS.
Interventions
DRUG25% intravenous (IV) sodium thiosulfate
50 ml IV drip twice/week post hemodialysis
Sponsors
Ramathibodi Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* CAC score \> 300 * Life expectancy \> 6 months * Dialysis vintage \> 6 months
Exclusion criteria
* Non-compliance to hemodialysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CAC score | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Bone mineral density, calcium removal | 6 months, 1 and 2 months |
Countries
Thailand
Outcome results
None listed