Coronally Advanced Flap in Combination With Acellular Dermal Matrix and Enamel Matrix Derivatives for Root Coverage

Coronally Advanced Flap in Combination With Acellular Dermal Matrix With or Without Enamel Matrix Derivatives for Root Coverage

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00720707

Enrollment

Registered

2008-07-23

Start date

2006-04-30

Completion date

2007-03-31

Last updated

2008-07-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival Recession

Keywords

Coronally advanced flap, gingival recession, enamel matrix protein, acellular dermal matrix, root coverage

Brief summary

The aim of this study is to compare the clinical outcomes of root coverage procedures, using coronally advanced flap in combination with acellular dermal matrix with or without enamel matrix derivatives .

Detailed description

coverage of gingival recession defects has been considered as a matter of interest for dental practitioners.subjects with a paired gingival recession defect will be selected from the patients who sought dental treatment at our department.Random allocation of the treatment sites to test (CAF+ EMD+ADM) and control (CAF + ADM) groups will be performed by a person who is external to the study and using a computerized selection of random numbers for allocation of the study groups.The parameters of the study are as following items: probing depth( PD), clinical attachment level (CAL), width of keratinized tissue (WKT), recession depth from cemento- enamel junction (RD), recession width (RW), distance between mucogingival junction and the stent (MGJ), Plaque (PI) and gingival (GI) indices and root coverage percentage (RC) and the patients will be followed up for 6 months.

Interventions

PROCEDURECAF+ADM+EMD

using coronally advanced flap (CAF) in combination with acellular dermal matrix (ADM) with enamel matrix derivatives (EMD).

PROCEDURECAF+ADM

using coronally advanced flap (CAF) in combination with acellular dermal matrix (ADM) without enamel matrix derivatives (EMD) for root coverage procedures.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Having no systemic disease affecting the periodontium, * No contraindication for elective surgery, * Adequate oral hygiene , * No previous surgical attempts for root coverage at the studying sites, * Vital teeth and signing a witness letter.

Exclusion criteria

* Smoking, presence of a restorations on tooth surface for test and control teeth, * Pregnancy, * Being under treatment with steroids, * Peri-apical infection, * Indication for antibiotic prophylaxis prior to dental treatments

Design outcomes

Primary

Measure	Time frame
the percentage of root coverage	at baseline, 2 and 6 months after treatment.

Secondary

Measure	Time frame
clinical attachment level, width of keratinized gingiva ant the position of mucco-gingival junction following root coverage procedures	6 months after treatment

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026