Pulsatile and Steady State Hemodynamics in Diastolic Heart Failure

Diagnostic Value of Measures of Pulsatile Versus Steady State Hemodynamics in Diastolic Heart Failure

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00720525

Enrollment

362

Registered

2008-07-22

Start date

2008-04-30

Completion date

2011-07-31

Last updated

2011-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diastolic Heart Failure

Keywords

arterial stiffness, arterial wave reflections, diastolic heart failure

Brief summary

Over the past few years, there has been a growing appreciation that a large number of patients with heart failure have a relatively normal (or preserved) ejection fraction (NFNEF). Epidemiologically, HFNEF is most prevalent among elderly women, most of whom have hypertension, diabetes, or both and often coronary artery disease (CAD). Increased arterial stiffness and/or wave reflections have been described in the same patient groups. Therefore, the investigators speculate that pulsatile hemodynamics, representing arterial stiffness and/or arterial wave reflections, 1) may be altered in HFNEF patients, 2) this may contribute to pathophysiology of HFNEF, and 3) this may be used for the diagnosis of the syndrome.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* exertional dyspnea * undergoing heart catheterization for diagnosis or exclusion of coronary artery disease * normal EF (\> 50%)

Exclusion criteria

* atrial fibrillation * more than mild valvular heart disease * pericardial disease * no informed consent

Countries

Austria

Outcome results