Incidence and Patterns of Nausea/Vomiting With Combined Chemotherapy and Radiation

A Prospective Study to Evaluate the Incidence and Patterns of Nausea and Vomiting in Patients Receiving Combined Chemotherapy and Radiation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00716157

Enrollment

Registered

2008-07-16

Start date

2004-10-31

Completion date

2011-09-30

Last updated

2014-12-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer of the Esophagus, Cancer of the Head and Neck, Cancer of the Lung, Gastro-esophageal Junction Cancer

Brief summary

Questionnaire study to observe the incidence and pattern or nausea and vomiting in patients receiving combined chemotherapy and radiation. 83% of patients experience radiation therapy-induced vomiting; significant nausea and vomiting could develop with concurrent chemotherapy despite standard anti-nauseous medication prophylaxis.

Detailed description

Questionnaires will be answered daily on a weekly basis during period of radiation and chemotherapy.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Concurrent radiation and chemotherapy treatment * Aerodigestive malignancy

Exclusion criteria

* Other causes of vomiting (i.e.gastrointestinal obstruction...)

Design outcomes

Primary

Measure	Time frame
Assess incidence and patterns of nausea and vomiting in patients undergoing concurrent chemotherapy and radiation	week of treatment

Secondary

Measure	Time frame
Assess the impact of nausea and vomiting on the patients' daily functioning	week of treatment
Study the incidence of mucositis and esophagitis	week of treatment

Countries

United States

Outcome results