Arrhythmias, Cardiac
Conditions
Keywords
Children, Cardiac Arrhythmia, General Anesthesia
Brief summary
To describe the types and incidence of cardiac dysrhythmias that occur under anesthesia in the present anesthesia environment.
Detailed description
It is unclear what the current state of anesthesia associated dysrhythmias is in the pediatric population. This was last investigated retrospectively in 1992 when the predominant volatile agent used for inhalation induction was halothane. Sevoflurane was approved by the Food and Drug Administration in 1995. Since that time, Sevoflurane has displaced halothane as the agent of choice for inhalation induction and has relegated halothane to be used in a narrow niche which primarily involves patients with very specific congenital heart diseases. It has been described that halothane has a larger proarrhythmic effect than sevoflurane for ventricular dysrhythmias. With the transition from the halothane to the sevoflurane era, a reassessment of the incidence and types of dysrhythmias occurring in non-cardiac pediatric patients is important.
Interventions
None listed
Sponsors
Children's Anesthesiology Associates, Ltd.
Children's Hospital of Philadelphia
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
Children, while under anesthesia, having 1. circumstances of tachycardia and bradycardia, 2. administration of medications used in the treatment of dysrhythmias, 3. the commentary which includes comment about the heart rhythm or therapy for dysrhythmia, 4. in the quality assurance database for evidence of dysrhythmia
Exclusion criteria
Children with a known pre-operative: 1. prior history of dysrhythmia and/or 2. residual congenital heart disease 3. anti/pro dysrhythmic medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arrhythmias During General Anesthesia in Children | July 1998 through July 2004 |
Countries
United States
Participant flow
Recruitment details
We performed a retrospective chart review of anesthetics administered at The Children's Hospital of Philadelphia from July 1998 through July 2004.
Pre-assignment details
Excluded were patients with known arrhythmias or pro-arrhythmic conditions, patients with congenital heart disease and patients undergoing cardiac surgery or cardiac catheterization.
Participants by arm
| Arm | Count |
|---|---|
| Children With Dysrhythmia Events During Anesthesia The sample of patients screened will be the entire electronic anesthesia record database from 1998 until 2004 looking for subjects that have dysrhythmias. | 234 |
| Total | 234 |
Baseline characteristics
| Characteristic | Children With Dysrhythmia Events During Anesthesia |
|---|---|
| Age, Categorical <=18 years | 234 Participants |
| Age, Categorical >=65 years | 0 Participants |
| Age, Categorical Between 18 and 65 years | 0 Participants |
| Children with potential intraoperative dysrhythmias | 234 participants |
| Region of Enrollment United States | 234 participants |
| Sex: Female, Male Female | 100 Participants |
| Sex: Female, Male Male | 134 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 0 / 0 |
| serious Total, serious adverse events | 0 / 0 |
Outcome results
Primary
Arrhythmias During General Anesthesia in Children
Time frame: July 1998 through July 2004
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Children With Dysrhythmia Events During Anesthesia | Arrhythmias During General Anesthesia in Children | 220 participants |