The EVLW for Set the Positive End Expiratory Pressure (PEEP) in the Acute Respiratory Distress Syndrome (ARDS)

Predictive Value of the Extra-Vascular Lung Water (EVLW) for the Alveolar Recruitment in the Acute Respiratory Distress Syndrome ( ARDS ).

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00714987

Enrollment

Registered

2008-07-14

Start date

2009-01-31

Completion date

2009-02-28

Last updated

2009-09-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Respiratory Distress Syndrome

Keywords

ARDS, Mechanical ventilation, PEEP with low level, PEEP with high level, EVLW, Picco® system, PaO2/FiO2 ratio

Brief summary

* ARDS is a severe pathology with high mortality and morbidity.Actual ventilatory management is clear for the set of the tidal volume and for the survey of the plateau pressure for the patients who require mechanical ventilation. * The set of the PEEP (low or high levels) remains unclear : it seems that some patients need low levels of PEEP whereas anther need high levels; but there is no validated data that can discriminate them. * We hypothesized that patients with low levels of EVLW ( measured with the Picco® system ) need low level of PEEP to ameliorate their oxygenation ( measured with the PaO2/FiO2 ratio ) whereas patients with high levels of EVLW) need high levels of PEEP.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* age\>18; * ARDS criteria.

Exclusion criteria

* severe pulmonary hypertension; * chronic right ventricular failure; * pulmonary embolism; * tricuspidian valvulopathy; * history of spontaneous pneumothorax; * severe emphysema; * bronchomalacia; * recent pulmonary surgery; * BMI\>40; * Interstitial pulmonary fibrosis; * End of life; * Chronic neuromyopathie; * Recent neurosurgery or intracranian hypertension; * Pregnancy.

Design outcomes

Primary

Measure	Time frame
Estimate the Lung Water Extra-Vascular as predictive marker of the answer (Variation of needs in oxygen) to the ventilatory strategy: the low level, and high level of pressure positive expiratory, in the SDRA	During all the period of stay of the patient Intensive care unit

Outcome results