Major Depressive Disorder
Conditions
Keywords
Major depressive Disorder, fluoxetine, short-term psychodynamic psychotherapy, PET
Brief summary
In this study we compare two treatments for major depression - fluoxetine and brief psychodynamic psychotherapy. In addition to more traditional outcome measures, we also measure the densities of 5HT-1A and D-2 receptors before and after the treatment. The main hypothesis is that brief psychotherapy is as effective as fluoxetine.
Detailed description
This study is a randomized comparison of two treatments for major depression - fluoxetine and brief psychodynamic psychotherapy. The patients are recruited from occupational health services and suffer from mild to moderate major depressive disorder. The treatments last for 16 weeks. The main outcome measures include HAM-D, BDI, SOFAS, Rand-36. In addition to more traditional outcome measures, we also measure the densities of 5HT-1A and D-2 receptors before and after the treatment using Positron Emission Tomography (PET) . The main hypothesis is that brief psychotherapy is as effective as fluoxetine, but differences between the treatments are seen in PET scanning.
Interventions
DRUGFluoxetine
20-40 mg / day orally
BEHAVIORALShort-term psychodynamic psychotherapy
1 session / week for 16 weeks
Sponsors
KELA
Finnish State Grant
University of Turku
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* MDD (mild to moderate) * HDRS 15 or more, age 20-60 years * No treatment for preceding 4 months * No DSM-IV axis I or II comorbidity * No severe somatic illness * No contraindications for fluoxetine treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAM-D | 0, 16 weeks, one year |
Outcome results
None listed