Propofol Versus Volatile Anesthesia in Post Operative Pain Management

Do Patients Anesthetized With Propofol Have Less Pain Than Those Anesthetized With Volatile?

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00712517

Enrollment

Registered

2008-07-10

Start date

2010-09-30

Completion date

2014-05-31

Last updated

2016-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain, Varicose Vein

Keywords

postoperative pain, Piritramid, propofol, sevoflurane, varicose vein, Anesthesia

Brief summary

The study will test the hypothesis that patients anesthetized with propofol suffer less postoperative pain than those anesthetized with sevoflurane.

Detailed description

Patients undergoing s stripping operation for varicose veins will be randomized to one of two groups. Group 1 patients will receive propofol anesthesia. Group 2 patients will receive sevoflurane anesthesia. Intraoperative measurements including mean-arterial pressure, heart rate, propofol infusion rate, remifentanil infusion rate, and end-tidal sevoflurane concentration will be taken at 15 minute intervals. Patients in both groups will receive Piritramid as necessary to control pain either intravenously or through patient controlled pump. VAS pain score, mean-arterial pressure, heart rate, nausea will be evaluated at 30 minute intervals during the first four postoperative hours. Piritramid dosage and vomiting will be recorded through the first postoperative morning. Patients will rate pain based on the VAS score for the period between leaving the recovery room and the first postoperative morning

Interventions

DRUGpropofol

propofol anesthesia 3-5mg/kg

DRUGsevoflurane

sevoflurane anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Participants will undergo a stripping operation for varicose veins * Surgery will be performed by one physician only * Written informed consent

Exclusion criteria

* Any contraindications to the proposed interventions * Procedures done under regional anesthesia

Design outcomes

Primary

Measure	Time frame
The primary outcome is morphine-equivalent use from the end of surgery until the first post-operative morning.	first post operative morning

Secondary

Measure	Time frame
To determine the average pain score for each group during the first four hours of recovery after surgery.	30 minute intervals for first 4 hours post operatively

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 12, 2026