Cataract
Conditions
Keywords
Discovisc, Ophthalmic Viscosurgical Device
Brief summary
A comparison of the ability of DisCoVisc to that of other ophthalmic viscosurgical devices (OVDs) (DuoVisc, Healon5 or Amvisc PLUS) regarding endothelial protection and anterior chamber space maintenance during non-eventful cataract surgery.
Interventions
DEVICEDisCoVisc
Use of DisCoVisc Ophthalmic Viscosurgical Device (4% sodium chondroitin sulfate, 1.65% sodium hyaluronate) during cataract surgery.
DEVICEDuoVisc
Use of DuoVisc viscoelastic system consisting of Viscoat (3% sodium hyaluronate, 4% chondroitin sulfate)and Provisc(1% sodium hyaluronate) during cataract surgery.
DEVICEHealon5
Use of Healon5 ophthalmic viscosurgical device (2.3% Sodium Hyaluronate) during cataract surgery.
DEVICEAmvisc Plus
Use of Amvisc Plus ophthalmic viscosurgical device (1.6% Sodium Hyaluronate) during cataract surgery.
Sponsors
Alcon Research
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* operable cataracts in at least one eye
Exclusion criteria
* Endothelial Cell Count (ECC) ≤1500cells/mm2 * Intraocular Pressure (IOP) \> 21mm Hg * previous ocular inflammation * systemic or ocular conditions affecting corneal endothelium
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Corneal Endothelial Cell Loss | 1 month after surgery | Percentage of corneal endothelial cells lost 1 month after surgery as compared to the number of corneal endothelial cells measured before surgery. Corneal endothelial cells are measured by counting the number of cells on an image taken by specular microscope. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percent Gain in Corneal Thickness. | 1 week and month after surgery | Percent Gain in Corneal Thickness between the assessment performed before surgery to that performed after surgery. This was assessed at both the 1 week and 1 month visit. Corneal thickness is measured in micrometers and is evaluated by Pachymetry. A negative number indicates a decrease in corneal thickness. |
| Aqueous Signs - Corneal Edema | 1 day after surgery | Measured as the percentage of patient's eyes subjectively evaluated to have corneal edema at each of the following gradings: 0 - none; 1 - Mild, slight localized or generalized edema; 2 - Moderate, significant localized or generalized edema; 3 - Severe, advanced localized or generalized edema. |
| Aqueous Signs - Aqueous Flare | 1 Day after Surgery | Measured as the percentage of patient's eyes subjectively evaluated to have Aqueous Flare at each of the following gradings: 0 - None: No visible flare when compared to the normal eye, 1 - Mild: Flare visible against dark papillary background but not visible against iris background, 2 - Moderate: Flare is visible with the slit-lamp beam aimed onto the iris surface as well as teh dark papillary background, 3 - Severe: Very dense flare. May also present as a hazy appearance of anterior segment structures when viewed with low power magnification of the slit-lamp. |
| Intraocular Pressure (IOP) | 1 day after surgery | Measure of intraocular pressure of a patient's eye via tonometry one day after surgery. Measured in mmHg. Normal intraocular pressure is between 10 mmHg and 20 mmHg. |
| Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Time of surgery | Surgeon reporting of Anterior Chamber Dome Maintenance of a subject's eye during anterior capsulotomy. Evaluated on a subjective scale and reported as percent by response. The following scale is used, from worst to best: Flat, Shallow, Working Space Adequate, Full Chamber Maintenance. |
| Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Time of Surgery | Surgeon reporting of Anterior Chamber Dome Maintenance of a subject's eye during phacoemulsification. Evaluated on a subjective scale and reported as percent by response. The following scale is used, from worst to best: Flat, Shallow, Working Space Adequate, Full Chamber Maintenance. |
| Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Time of Surgery | Surgeon reporting of Anterior Chamber Dome Maintenance of a subject's eye during intraocular lens (IOL) insertion. Evaluated on a subjective scale and reported as percent by response. The following scale is used, from worst to best: Flat, Shallow, Working Space Adequate, Full Chamber Maintenance. |
| Aqueous Signs - Aqueous Cells | 1 day after surgery | Measured as the percentage of patient's eyes subjectively evaluated to have Aqueous Cells at each of the following gradings: 0 - None, 1 - 1 to 5 cells, 2 - 6 to 15 cells, 3 - 16 - 30 cells, 4 - \>30 cells. |
Countries
United States
Participant flow
Recruitment details
Subjects were \>50 years old & of any race & gender. Subjects had operable cataracts in at least 1 eye, were able to provide informed consent, & were free of systemic diseases affecting ocular health, especially those affecting endothelial cell counts. Eyes were free of ocular disease & had no history of chronic/recurrent inflammatory eye disease.
Pre-assignment details
During the preoperative exam, subjects were examined to ensure they met the inclusion/exclusion criteria. Only subjects who signed an informed consent and qualified to be in the study by meeting all inclusion/exclusion criteria were enrolled. Group assignment was based on an Excel randomization scheme.
Participants by arm
| Arm | Count |
|---|---|
| DISCOVISC DISCOVISC® Ophthalmic Viscosurgical Device (OVD) | 29 |
| DUOVISC DUOVISC® Viscoelastic system | 29 |
| Healon5 Healon5 Ophthalmic Viscosurgical Device | 27 |
| Amvisc Plus Amvisc Plus Ophthalmic Viscosurgical Device | 27 |
| Total | 112 |
Baseline characteristics
| Characteristic | DISCOVISC | DUOVISC | Healon5 | Amvisc Plus | Total |
|---|---|---|---|---|---|
| Age Categorical <=18 years | 0 participants | 0 participants | 0 participants | 0 participants | 0 participants |
| Age Categorical >=65 years | 16 participants | 15 participants | 18 participants | 18 participants | 67 participants |
| Age Categorical Between 18 and 65 years | 12 participants | 12 participants | 9 participants | 8 participants | 41 participants |
| Gender Female | 18 participants | 15 participants | 16 participants | 19 participants | 68 participants |
| Gender Male | 10 participants | 12 participants | 11 participants | 7 participants | 40 participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk |
|---|---|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — | — / — | — / — |
| other Total, other adverse events | 0 / 29 | 0 / 29 | 0 / 27 | 0 / 27 |
| serious Total, serious adverse events | 0 / 29 | 0 / 29 | 0 / 27 | 0 / 27 |
Outcome results
Primary
Corneal Endothelial Cell Loss
Percentage of corneal endothelial cells lost 1 month after surgery as compared to the number of corneal endothelial cells measured before surgery. Corneal endothelial cells are measured by counting the number of cells on an image taken by specular microscope.
Time frame: 1 month after surgery
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| DISCOVISC | Corneal Endothelial Cell Loss | 1.51 Percent Change | Standard Deviation 5.99 |
| DUOVISC | Corneal Endothelial Cell Loss | 1.18 Percent Change | Standard Deviation 11.18 |
| Healon5 | Corneal Endothelial Cell Loss | 4.72 Percent Change | Standard Deviation 7.23 |
| Amvisc Plus | Corneal Endothelial Cell Loss | 6.30 Percent Change | Standard Deviation 14.31 |
Secondary
Aqueous Signs - Aqueous Cells
Measured as the percentage of patient's eyes subjectively evaluated to have Aqueous Cells at each of the following gradings: 0 - None, 1 - 1 to 5 cells, 2 - 6 to 15 cells, 3 - 16 - 30 cells, 4 - \>30 cells.
Time frame: 1 day after surgery
Population: This data was collected for all subjects attending the visit one day after surgery.
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| DISCOVISC | Aqueous Signs - Aqueous Cells | Grade 2 | 24.14 Percentage of participants |
| DISCOVISC | Aqueous Signs - Aqueous Cells | Grade 3 | 3.45 Percentage of participants |
| DISCOVISC | Aqueous Signs - Aqueous Cells | Grade 0 | 6.9 Percentage of participants |
| DISCOVISC | Aqueous Signs - Aqueous Cells | Grade 1 | 65.52 Percentage of participants |
| DISCOVISC | Aqueous Signs - Aqueous Cells | Grade 4 | 0 Percentage of participants |
| DUOVISC | Aqueous Signs - Aqueous Cells | Grade 2 | 32.14 Percentage of participants |
| DUOVISC | Aqueous Signs - Aqueous Cells | Grade 3 | 7.14 Percentage of participants |
| DUOVISC | Aqueous Signs - Aqueous Cells | Grade 1 | 46.43 Percentage of participants |
| DUOVISC | Aqueous Signs - Aqueous Cells | Grade 0 | 14.29 Percentage of participants |
| DUOVISC | Aqueous Signs - Aqueous Cells | Grade 4 | 0 Percentage of participants |
| Healon5 | Aqueous Signs - Aqueous Cells | Grade 2 | 38.46 Percentage of participants |
| Healon5 | Aqueous Signs - Aqueous Cells | Grade 0 | 7.69 Percentage of participants |
| Healon5 | Aqueous Signs - Aqueous Cells | Grade 1 | 50 Percentage of participants |
| Healon5 | Aqueous Signs - Aqueous Cells | Grade 3 | 3.85 Percentage of participants |
| Healon5 | Aqueous Signs - Aqueous Cells | Grade 4 | 0 Percentage of participants |
| Amvisc Plus | Aqueous Signs - Aqueous Cells | Grade 3 | 3.85 Percentage of participants |
| Amvisc Plus | Aqueous Signs - Aqueous Cells | Grade 1 | 65.38 Percentage of participants |
| Amvisc Plus | Aqueous Signs - Aqueous Cells | Grade 0 | 7.69 Percentage of participants |
| Amvisc Plus | Aqueous Signs - Aqueous Cells | Grade 2 | 23.08 Percentage of participants |
| Amvisc Plus | Aqueous Signs - Aqueous Cells | Grade 4 | 0 Percentage of participants |
Secondary
Aqueous Signs - Aqueous Flare
Measured as the percentage of patient's eyes subjectively evaluated to have Aqueous Flare at each of the following gradings: 0 - None: No visible flare when compared to the normal eye, 1 - Mild: Flare visible against dark papillary background but not visible against iris background, 2 - Moderate: Flare is visible with the slit-lamp beam aimed onto the iris surface as well as teh dark papillary background, 3 - Severe: Very dense flare. May also present as a hazy appearance of anterior segment structures when viewed with low power magnification of the slit-lamp.
Time frame: 1 Day after Surgery
Population: This data was collected for all subjects attending the visit one day after surgery.
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| DISCOVISC | Aqueous Signs - Aqueous Flare | None | 20.69 Percentage of participants |
| DISCOVISC | Aqueous Signs - Aqueous Flare | Mild | 75.86 Percentage of participants |
| DISCOVISC | Aqueous Signs - Aqueous Flare | Moderate | 3.45 Percentage of participants |
| DISCOVISC | Aqueous Signs - Aqueous Flare | Severe | 0 Percentage of participants |
| DUOVISC | Aqueous Signs - Aqueous Flare | Mild | 53.57 Percentage of participants |
| DUOVISC | Aqueous Signs - Aqueous Flare | Moderate | 7.14 Percentage of participants |
| DUOVISC | Aqueous Signs - Aqueous Flare | Severe | 0 Percentage of participants |
| DUOVISC | Aqueous Signs - Aqueous Flare | None | 39.29 Percentage of participants |
| Healon5 | Aqueous Signs - Aqueous Flare | Moderate | 7.69 Percentage of participants |
| Healon5 | Aqueous Signs - Aqueous Flare | Mild | 65.38 Percentage of participants |
| Healon5 | Aqueous Signs - Aqueous Flare | Severe | 0 Percentage of participants |
| Healon5 | Aqueous Signs - Aqueous Flare | None | 26.92 Percentage of participants |
| Amvisc Plus | Aqueous Signs - Aqueous Flare | Severe | 0 Percentage of participants |
| Amvisc Plus | Aqueous Signs - Aqueous Flare | Mild | 53.85 Percentage of participants |
| Amvisc Plus | Aqueous Signs - Aqueous Flare | None | 46.15 Percentage of participants |
| Amvisc Plus | Aqueous Signs - Aqueous Flare | Moderate | 0 Percentage of participants |
Secondary
Aqueous Signs - Corneal Edema
Measured as the percentage of patient's eyes subjectively evaluated to have corneal edema at each of the following gradings: 0 - none; 1 - Mild, slight localized or generalized edema; 2 - Moderate, significant localized or generalized edema; 3 - Severe, advanced localized or generalized edema.
Time frame: 1 day after surgery
Population: This data was collected for all subjects attending the visit one day after surgery.
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| DISCOVISC | Aqueous Signs - Corneal Edema | None | 68.97 Percentage of Participants |
| DISCOVISC | Aqueous Signs - Corneal Edema | Mild | 57.59 Percentage of Participants |
| DISCOVISC | Aqueous Signs - Corneal Edema | Moderate | 3.45 Percentage of Participants |
| DISCOVISC | Aqueous Signs - Corneal Edema | Severe | 0 Percentage of Participants |
| DUOVISC | Aqueous Signs - Corneal Edema | Mild | 21.43 Percentage of Participants |
| DUOVISC | Aqueous Signs - Corneal Edema | Moderate | 3.57 Percentage of Participants |
| DUOVISC | Aqueous Signs - Corneal Edema | Severe | 0 Percentage of Participants |
| DUOVISC | Aqueous Signs - Corneal Edema | None | 75 Percentage of Participants |
| Healon5 | Aqueous Signs - Corneal Edema | Moderate | 7.69 Percentage of Participants |
| Healon5 | Aqueous Signs - Corneal Edema | Mild | 34.62 Percentage of Participants |
| Healon5 | Aqueous Signs - Corneal Edema | Severe | 0 Percentage of Participants |
| Healon5 | Aqueous Signs - Corneal Edema | None | 57.69 Percentage of Participants |
| Amvisc Plus | Aqueous Signs - Corneal Edema | Severe | 0 Percentage of Participants |
| Amvisc Plus | Aqueous Signs - Corneal Edema | Mild | 34.62 Percentage of Participants |
| Amvisc Plus | Aqueous Signs - Corneal Edema | None | 65.38 Percentage of Participants |
| Amvisc Plus | Aqueous Signs - Corneal Edema | Moderate | 0 Percentage of Participants |
Secondary
Intraocular Pressure (IOP)
Measure of intraocular pressure of a patient's eye via tonometry one day after surgery. Measured in mmHg. Normal intraocular pressure is between 10 mmHg and 20 mmHg.
Time frame: 1 day after surgery
Population: This data was collected on all subjects attending the visit one day after surgery with the exception of 3 DisCoVisc subjects, 4 DuoVisc subjects, 2 Healon5 subjects, and 1 AmVisc Plus subject.
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| DISCOVISC | Intraocular Pressure (IOP) | 21.58 mmHg | Standard Deviation 8.42 |
| DUOVISC | Intraocular Pressure (IOP) | 19.48 mmHg | Standard Deviation 4.6 |
| Healon5 | Intraocular Pressure (IOP) | 20.72 mmHg | Standard Deviation 6.61 |
| Amvisc Plus | Intraocular Pressure (IOP) | 18.65 mmHg | Standard Deviation 5.56 |
Secondary
Percent Gain in Corneal Thickness.
Percent Gain in Corneal Thickness between the assessment performed before surgery to that performed after surgery. This was assessed at both the 1 week and 1 month visit. Corneal thickness is measured in micrometers and is evaluated by Pachymetry. A negative number indicates a decrease in corneal thickness.
Time frame: 1 week and month after surgery
Population: Participants analyzed for Baseline to 1 week: 29 DisCovisc, 28 DuoVisc, 26 Healon5, 26 Amvisc Plus.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| DISCOVISC | Percent Gain in Corneal Thickness. | Before Surgery to 1 Week after Surgery | 2.89 Percent Gain | Standard Deviation 16.45 |
| DISCOVISC | Percent Gain in Corneal Thickness. | Before Surgery to 1 Month after Surgery | -0.55 Percent Gain | Standard Deviation 11.79 |
| DUOVISC | Percent Gain in Corneal Thickness. | Before Surgery to 1 Month after Surgery | -1.06 Percent Gain | Standard Deviation 25.38 |
| DUOVISC | Percent Gain in Corneal Thickness. | Before Surgery to 1 Week after Surgery | 7.02 Percent Gain | Standard Deviation 12.06 |
| Healon5 | Percent Gain in Corneal Thickness. | Before Surgery to 1 Week after Surgery | 9.92 Percent Gain | Standard Deviation 15.29 |
| Healon5 | Percent Gain in Corneal Thickness. | Before Surgery to 1 Month after Surgery | 1.98 Percent Gain | Standard Deviation 10.57 |
| Amvisc Plus | Percent Gain in Corneal Thickness. | Before Surgery to 1 Week after Surgery | 5.06 Percent Gain | Standard Deviation 12.07 |
| Amvisc Plus | Percent Gain in Corneal Thickness. | Before Surgery to 1 Month after Surgery | -9.11 Percent Gain | Standard Deviation 22.85 |
Secondary
Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion
Surgeon reporting of Anterior Chamber Dome Maintenance of a subject's eye during intraocular lens (IOL) insertion. Evaluated on a subjective scale and reported as percent by response. The following scale is used, from worst to best: Flat, Shallow, Working Space Adequate, Full Chamber Maintenance.
Time frame: Time of Surgery
Population: This data was collected on all subjects undergoing surgery with the exception of 1 DuoVisc subject.
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| DISCOVISC | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Working Space Adequate | 0 Percentage of participants |
| DISCOVISC | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Shallow | 0 Percentage of participants |
| DISCOVISC | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Flat | 0 Percentage of participants |
| DISCOVISC | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Full Chamber Maintenance | 100 Percentage of participants |
| DUOVISC | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Shallow | 0 Percentage of participants |
| DUOVISC | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Flat | 0 Percentage of participants |
| DUOVISC | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Working Space Adequate | 7.14 Percentage of participants |
| DUOVISC | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Full Chamber Maintenance | 92.86 Percentage of participants |
| Healon5 | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Flat | 0 Percentage of participants |
| Healon5 | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Working Space Adequate | 25.93 Percentage of participants |
| Healon5 | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Shallow | 40.74 Percentage of participants |
| Healon5 | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Full Chamber Maintenance | 33.33 Percentage of participants |
| Amvisc Plus | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Shallow | 7.41 Percentage of participants |
| Amvisc Plus | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Working Space Adequate | 44.44 Percentage of participants |
| Amvisc Plus | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Full Chamber Maintenance | 48.15 Percentage of participants |
| Amvisc Plus | Surgeon Surgey - Anterior Dome Maintenance During Intraocular Lens (IOL) Insertion | Flat | 0 Percentage of participants |
Secondary
Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification
Surgeon reporting of Anterior Chamber Dome Maintenance of a subject's eye during phacoemulsification. Evaluated on a subjective scale and reported as percent by response. The following scale is used, from worst to best: Flat, Shallow, Working Space Adequate, Full Chamber Maintenance.
Time frame: Time of Surgery
Population: This data was collected on all subjects undergoing surgery with the exception of 1 DuoVisc subject.
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| DISCOVISC | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Flat | 0 Percentage of participants |
| DISCOVISC | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Shallow | 0 Percentage of participants |
| DISCOVISC | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Working Space Adequate | 0 Percentage of participants |
| DISCOVISC | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Full Chamber Maintenance | 100 Percentage of participants |
| DUOVISC | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Shallow | 0 Percentage of participants |
| DUOVISC | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Working Space Adequate | 3.57 Percentage of participants |
| DUOVISC | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Full Chamber Maintenance | 96.43 Percentage of participants |
| DUOVISC | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Flat | 0 Percentage of participants |
| Healon5 | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Working Space Adequate | 51.85 Percentage of participants |
| Healon5 | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Shallow | 11.11 Percentage of participants |
| Healon5 | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Full Chamber Maintenance | 37.04 Percentage of participants |
| Healon5 | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Flat | 0 Percentage of participants |
| Amvisc Plus | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Full Chamber Maintenance | 48.15 Percentage of participants |
| Amvisc Plus | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Shallow | 3.7 Percentage of participants |
| Amvisc Plus | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Flat | 0 Percentage of participants |
| Amvisc Plus | Surgeon Surgey - Anterior Dome Maintenance During Phacoemulsification | Working Space Adequate | 48.15 Percentage of participants |
Secondary
Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy
Surgeon reporting of Anterior Chamber Dome Maintenance of a subject's eye during anterior capsulotomy. Evaluated on a subjective scale and reported as percent by response. The following scale is used, from worst to best: Flat, Shallow, Working Space Adequate, Full Chamber Maintenance.
Time frame: Time of surgery
Population: This data was collected on all subjects undergoing surgery with the exception of 1 DuoVisc subject.
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| DISCOVISC | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Flat | 0 Percentage of participants |
| DISCOVISC | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Shallow | 3.45 Percentage of participants |
| DISCOVISC | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Working Space Adequate | 0 Percentage of participants |
| DISCOVISC | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Full Chamber Maintenance | 96.55 Percentage of participants |
| DUOVISC | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Shallow | 3.57 Percentage of participants |
| DUOVISC | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Working Space Adequate | 7.14 Percentage of participants |
| DUOVISC | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Full Chamber Maintenance | 89.29 Percentage of participants |
| DUOVISC | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Flat | 0 Percentage of participants |
| Healon5 | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Working Space Adequate | 48.15 Percentage of participants |
| Healon5 | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Shallow | 22.22 Percentage of participants |
| Healon5 | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Full Chamber Maintenance | 29.63 Percentage of participants |
| Healon5 | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Flat | 0 Percentage of participants |
| Amvisc Plus | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Full Chamber Maintenance | 25.93 Percentage of participants |
| Amvisc Plus | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Shallow | 18.52 Percentage of participants |
| Amvisc Plus | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Flat | 0 Percentage of participants |
| Amvisc Plus | Surgeon Survey - Anterior Chamber Dome Maintenance During Anterior Capsulotomy | Working Space Adequate | 55.56 Percentage of participants |