Manual and Expressed Placental Removal at Cesarean Delivery and Its Effects on Various Cardiac Indices

Manual and Expressed Placental Removal at Planned Cesarean Delivery and Its Effects on Various Cardiac Indices as Measured By Continuous Wave Doppler Ultrasonography

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00711451

Enrollment

Registered

2008-07-08

Start date

2008-07-31

Completion date

2012-01-31

Last updated

2012-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean Delivery, Pregnancy

Keywords

systemic vascular resistance, pregnancy, scheduled cesarean delivery, syncytiotrophoblast apoptosis, continuous wave Doppler

Brief summary

The purpose of this study is to evaluate whether manual removal of the placenta during a cesarean delivery results in higher changes in the resistance of blood flow throughout the body, also called systemic vascular resistance (SVR)

Detailed description

Patients presenting to William Beaumont Hospital Royal Oak Labor and Delivery for a scheduled low transverse cesarean delivery will be asked to participate in a prospective, randomized study to evaluate any changes in systemic vascular resistance (SVR) pre- and post-delivery. After obtaining informed consent, the patients will be randomized to one of two groups: group 1 will have manual removal of the placenta at cesarean section and group 2 will have expressed removal of the placenta at cesarean section. Both groups will have a pre-operative continuous wave Doppler evaluation and a post-operative continuous wave Doppler evaluation at 24 hours after delivery. Continuous wave Doppler evaluation will be used pre- and post-operatively to evaluate any changes in SVR.

Interventions

PROCEDUREExpressed removal

Surgeon will perform an expressed delivery of the placenta

BEHAVIORALManual removal

Manual removal of placenta during cesarean delivery

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* pregnant * scheduled for cesarean delivery * able to give informed consent

Exclusion criteria

* taking medications that may affect hemodynamics * unable to give informed consent

Design outcomes

Primary

Measure	Time frame
Hemodynamic profile, especially Systemic Vascular Resistance	immediately before and 24 hours after cesarean delivery

Secondary

Measure	Time frame
development of postpartum preeclampsia	within 1 week of delivery

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026