Asthma, Exercise Induced
Conditions
Keywords
Asthma, Exercise induced bronchospasm, Hyperpnea induced bronchospasm, leukotrienes, adenosine, exhaled breath condensate
Brief summary
This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.
Interventions
PROCEDUREHyperpnea challenge
5 minutes of dry air hyperpnea to induce bronchospasm
Sponsors
University of Vermont
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
12 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Physician diagnosed asthma * Age 12-75 yrs * FEV1 \> 70% predicted * HIB response \> 10 % * No smoking last 6 mo and \< 10 pack yrs * No URI last 4 weeks * No asthma exacerbation last 4 weks * Able to withhold SABA \> 8 hrs and LABA \> 24 hrs
Exclusion criteria
* Other lung disease * Cardiac disease or other condition that would preclude safe participation, on theophylline or leukotriene modifiers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in level of cystLTs and adenosine | Before and after hyperpnea challenge |
Secondary
| Measure | Time frame |
|---|---|
| Change in pH of EBC and change in pulmonary function | Before and after hyperpnea challenge |
Countries
United States
Outcome results
None listed