Effect of Oral Sildenafil With Digital Therapeutic Iontophoresis of Sodium Nitroprussiate in Healthy Volunteers

Effect of Oral Sildenafil With Digital Therapeutic Iontophoresis of Sodium Nitroprussiate on Cutaneous Blood Flow in Healthy Volunteers

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00710099

Acronym

INFLUX-VS

Enrollment

Registered

2008-07-04

Start date

2008-07-31

Completion date

2011-06-30

Last updated

2011-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

iontophoresis, cutaneous microcirculation, sildenafil, Healthy volunteers

Brief summary

Iontophoresis is a employed to facilitate drug absorption without systemic effect. This study investigates cutaneous microcirculation when we associate sildenafil per os with SNP via iontophoresis.

Detailed description

The main outcome is the proof of concept of effect of systemic absorption sildenafil on cutaneous microcirculation associated with SNP iontophoresis.

Interventions

DRUGsildenafil

systemic absorption of sildenafil

DRUGnitroprussiate iontophoresis

nitroprussiate iontophoresis

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age over 18 * No significant medical history

Exclusion criteria

* Age under 18 * Period of exclusion for an other study * Pregnancy * Breast feeding * Severe disease * Cigarette smoking

Design outcomes

Primary

Measure	Time frame
variation of conductance of nitroprussiate iontophoresis associated with oral sildenafil	one hour

Secondary

Measure	Time frame
To assess the effect of oral sildenafil (50 mg and 100 mg) on skin microvascular reactivity to local cooling, on the forearm and the finger	one hour

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026