Multidetector Raw CT as a Single Tool in the Setting of Ischemic Stroke

Evaluation of Multidetector Raw Computerized Tomography in the Etiological Analysis of Acute Ischemic Stroke: the COCASE Protocol.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00708188

Acronym

COCASE

Enrollment

Registered

2008-07-02

Start date

2008-03-31

Completion date

2013-04-30

Last updated

2019-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Stroke

Keywords

Stroke, ischemic, etiology, TOAST, CT, multidetector

Brief summary

This is a prospective study including acute ischemic stroke patients aged 18 to 90. Multidetector raw CT is performed in acute ischemic stroke patients. Heart, neck vessels and brain arteries are studied during the same acquisition. Results are compared with the standard methods including transesophageal echocardiography (TEE), Doppler ultrasound (DUS) and MR angiography (MRA) of neck vessels. The main criteria is the ability of CT to classify the stroke etiology correctly according to the TOAST classification in comparison with the standard methods.

Interventions

DEVICEMultidetector raw CT

Multidetector raw CT

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Acute (\< 1 week) ischemic stroke patient aged 18 to 90 * Informed consent obtained * Presence of health insurance

Exclusion criteria

* Pregnancy or absence of efficient contraceptive method * Allergy * Allergy to contrast material * Asthma * Renal failure (blood creatinine \> 130 µmoles/l, creatinine clearance \< 80 ml/mn according to Cockroft method) * Myeloma * Hyperthyroidism (uncontrolled) * Difficulties to synchronize CT to heart rhythm * Contra-indication to TEE or MRI * Absence or retirement of informed consent * Absence of health insurance

Design outcomes

Primary

Measure	Time frame
Ability of CT to classify the stroke etiology correctly (TOAST classification) in comparison to reference methods (MRA, DUS, TEE)	classify the stroke etiology

Secondary

Measure	Time frame
Ability of CT to detect the source of stroke in each etiological group. Reliability of CT in quantitative measures of artery stenosis, aortic atheroma, heart thrombus, heart tumors). Tolerance of CT	detect the source of stroke

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026