Cesarean Section
Conditions
Keywords
pruritus, epidural morphine
Brief summary
Can epidural nalbuphine reduce incidence or severity of epidural morphine induced pruritus in patient undergoing cesarean section?
Detailed description
182 parturients,ASA 1-2 undergoing cesarean section under epidural block were enrolled in the study. After obtaining informed consent,all received epidural anesthesia using 2% lidocaine with epinephrine 1:200000 via epidural cathetes at L2-3 or L3-4 in a volume suffient to achieve a T4 sensory level bilaterally. After the umbilical cord was clamped,patients were assigned randomly to three groups.The placebo group,N-5 group,and N-10 group received 4 ml epidural solution containing morphine 4 mg plus either saline, nalbuphine 5 mg, and nalbuphine 10 mg respectively.At the post anesthetic care unit, intravenous pethidine PCA were administered for inadequate pain control. Outcome measures : Incidence and severity of postoperative pruritus Quality of pain control Side effects of epidural morphine and nalbuphine such as respiratory depression,sedation
Interventions
DRUGnalbuphine
nalbuphine 5 mg epidural
OTHERNSS
NSS
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* full term parturient undergoing elective cesarean section * ASA 1-2
Exclusion criteria
* drug or alcohol abuses * contraindication for regional anesthesia * received opioids within 12 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence and severity of pruritus | 24 hr |
Secondary
| Measure | Time frame |
|---|---|
| visual analogue pain score | 24 hr |
Countries
Thailand
Outcome results
None listed