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The Longevity Genes in Founder Populations Project

Searching for Longevity Genes in the Historically Unique Ashkenazi Jewish Population

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT00707694
Enrollment
2000
Registered
2008-07-01
Start date
1998-07-31
Completion date
2032-12-31
Last updated
2026-01-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Extreme Longevity

Keywords

95 years of age and older

Brief summary

We believe extreme longevity is due to specific genes which function to delay aging and prevent disease. The purpose of the research is to identify the genes/mutations associated with healthier aging; to understand the biological functions of these genes/mutations; and to develop therapies to replicate these preservative genetic activities in individuals who do not have the genetic profile for longevity.

Interventions

None listed

Sponsors

National Institute on Aging (NIA)
CollaboratorNIH
American Federation for Aging Research
CollaboratorOTHER
Weill Medical College of Cornell University
CollaboratorOTHER
Boston University
CollaboratorOTHER
Regeneron Pharmaceuticals
CollaboratorINDUSTRY
Harvard Medical School (HMS and HSDM)
CollaboratorOTHER
Stanford University
CollaboratorOTHER
Tufts Medical Center
CollaboratorOTHER
Columbia University
CollaboratorOTHER
University of Minnesota
CollaboratorOTHER
Rutgers Health
CollaboratorUNKNOWN
University of Rochester
CollaboratorOTHER
Albert Einstein College of Medicine
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Ashkenazi Jewish, age 95+, * Offspring of person age 95+, * Offspring of parents who died age 70 or younger.

Exclusion criteria

* Non-Ashkenazis

Countries

United States

Contacts

Primary ContactTina Gao
tina.gao@einsteinmed.edu718-839-7176

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026