Pre-diabetes
Conditions
Brief summary
Type 2 diabetes is a common metabolic disorder arising from a complex interaction between genetic predisposition and the environment. The development of this disorder is preceded by impaired glucose tolerance and elevated fasting glucose which also carry adverse cardiovascular risk. To date a few common genetic variants have been reliably associated with predisposition to type 2 diabetes. However, it is uncertain how these genes interact to alter insulin secretion and insulin action prior to the development of type 2 diabetes. We propose to utilize an established population-based cohort to determine how common genetic variants associated with type 2 diabetes alter the response to an oral glucose challenge in people without overt type 2 diabetes. This will enable us to understand how common variants alone or in combination alter whole-body glucose physiology and predispose to type 2 diabetes.
Interventions
OTHEROral glucose tolerance test
one time 75g oral glucose tolerance test for measurement of insulin secretion and action
Sponsors
University of Padova
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
35 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Fasting blood glucose \< 126mg/dL
Exclusion criteria
* Fasting blood glucose \> 126mg/dL
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Disposition Index | 2 hr | Measured by 7-sample, 2Hr OGTT |
Countries
United States
Outcome results
None listed