Embryo Aneuploidies
Conditions
Keywords
aneuploidies, natural cycle, stimulated cycle, preimplantation genetic diagnosis
Brief summary
There is a considerable concern about the effects of controlled ovarian hyperstimulation (COH) for In Vitro Fertilization- Embryo Transfer (IVF-ET) on embryo quality and on the incidence of chromosomal abnormalities in oocytes and embryos. The main question remaining is if COH may increase the aneuploidies rate in young and healthy women. Therefore, the primary endpoint of the present study is to analyse the incidence of chromosomal abnormalities in this group of patients (oocyte donors), either in oocytes obtained after a natural cycle or in those retrieved after a COH cycle. To get rid of the male factor influence, donated sperm will be used.
Interventions
PROCEDUREPreimplantation Genetic Diagnosis
Preimplantation Genetic Diagnosis (PGD) is performed on the embryos resulting from these natural and stimulated cycles.
Sponsors
Instituto Valenciano de Infertilidad, IVI VALENCIA
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
Donor Inclusion Criteria: * 18 to 35 years old. * BMI: 18-25Kg/m2 * Regular menstrual cycles * Normal kariotype * No previous controlled ovarian hyperstimulation (COH) treatments. Donor
Exclusion criteria
* Endometriosis * Policystic ovarian syndrome * Recurrent miscarriages. Recipient Inclusion Criteria * Aged until 45 years old * No systemic diseases * Following egg and sperm donation treatment. Recipient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Embryo aneuploidies | 2 cycles |
Countries
Spain
Outcome results
None listed