Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00706277

Enrollment

Registered

2008-06-27

Start date

2008-06-30

Completion date

2008-12-31

Last updated

2009-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Function

Keywords

forced vital capacity, forced expired volume in 1 s

Brief summary

The aim of the study is to investigate the effects of total intravenous anesthesia (TIVA; propofol, remifentanil) and balanced anesthesia (BAL; induction with propofol and fentanyl; maintenance of anesthesia with sevoflurane and nitrous oxide) on pulmonary function 30 minutes after emergence from the general anesthesia.

Interventions

DRUGpropofol

propofol 2mg/kg for induction of anesthesia; followed by propofol 6 mg/kg/hour

DRUGremifentanil

remifentanil 0,25mcg/kg/hour

DRUGfentanyl

fentanyl 100mcg

DRUGSevoflurane/Nitrous Oxide

maintenance of anesthesia with sevoflurane and nitrous oxide

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* ASA 1-2 * BMI normal

Exclusion criteria

* lung disease * Nicotine abuse

Design outcomes

Primary

Measure	Time frame
FEV1 forced expiratory volume; FVC forced vital capacity	preoperative, 30 minutes postoperative

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026