LCD Solution Versus Calcipotriol Cream in the Treatment of Moderate Plaque Psoriasis

A Randomized, Single-Blind, Active Control, 18-Week Study to Evaluate the Safety and Efficacy of A New Twice-Daily, Topically Applied LCD Solution vs. Calcipotriol Cream for the Treatment of Adult Subjects With Moderate Plaque Psoriasis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00705900

Enrollment

Registered

2008-06-27

Start date

2007-01-31

Completion date

2008-11-30

Last updated

2008-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Plaque Psoriasis

Keywords

psoriasis

Brief summary

The purpose of this study is to compare the safety and effectiveness of a new topical LCD solution and a commercially available calcipotriol (Vitamin D) cream in reducing the symptoms of plaque psoriasis and improving the quality of life in adults.

Interventions

DRUGLCD

2 applications / day for 12 weeks

DRUGcalcipotriol

2 applications / day for 12 weeks

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 18 years of age or older * able and willing to provide written informed consent * diagnosed with chronic plaque psoriasis * 3% to 15% body surface area involved * in good general health

Exclusion criteria

* other current treatments for psoriasis * renal or liver dysfunction * pregnant or nursing

Design outcomes

Primary

Measure	Time frame
Difference in percent reduction in Psoriasis Area and Severity Index (PASI) Scores between treatment arms	12 weeks of treatment

Secondary

Measure	Time frame
Changes in PLASI, PEASI, Physician Global Assessment (PGA), Pruritus, and Dermatology Life Quality Index (DLQI) Scores between treatment arms	Week 12 and Week 18

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026