Study Comparing CT Scan and Stress Test in Diagnosing Coronary Artery Disease in Patients Hospitalized for Chest Pain

A Randomized Trial Comparing Multi-Detector Coronary CT Angiography and Stress Myocardial Perfusion Imaging as the Initial Test for the Diagnosis of Coronary Artery Disease in Intermediate Risk Patients Admitted for Chest Pain

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00705458

Acronym

PROSPECT

Enrollment

400

Registered

2008-06-26

Start date

2008-07-31

Completion date

2013-12-31

Last updated

2015-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Coronary Syndrome, Angina Pectoris, Coronary Artery Disease, Unstable Angina

Keywords

stress myocardial perfusion imaging, coronary computed tomography angiography

Brief summary

The purpose of this study is to determine whether coronary artery CT scanning or nuclear stress testing is better at diagnosing chest pain patients with coronary artery disease to select appropriate candidates for coronary catheterization and re-vascularization.

Interventions

PROCEDURECoronary Computed Tomography Angiography

64-detector, retrospectively EKG-gated, computed tomography angiography of the coronary arteries during heart rate control (intravenous metoprolol, when necessary)

PROCEDUREStress Nuclear Myocardial Perfusion Imaging

Usually dual-isotope perfusion imaging at rest (201-Thallium) and at stress (99m-Technetium-MIBI). Some patients will have a 2-day MIBI protocol. Gated SPECT and attenuation-correction images will be obtained. Treadmill stress will be performed. If a patient is unable to exercise, adenosine or dobutamine will be given.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to No maximum

Healthy volunteers

Inclusion criteria

* patient admitted for chest pain or pressure * patient at intermediate short term risk of MI or death (AHA/ACC guidelines)

Exclusion criteria

* prior diagnosis of coronary artery disease * evidence of ongoing myocardial infarction (and other high risk criteria per AHA/ACC guidelines) * contraindications to EKG-gated CT scanning with iodinated intravenous contrast under beta-blockade * pregnancy * presence of an implanted pacemaker or defibrillator * stress myocardial perfusion imaging, coronary CTA or coronary catheterization within the last 6 months

Design outcomes

Primary

Measure	Time frame
Coronary catheterization that does not lead to re-vascularization	1 year

Secondary

Measure	Time frame
Length of Hospital Stay (time to discharge)	usually from hours to a few days (average about one day)
Non-fatal myocardial infarction	1 year
Death (all cause)	1 year
Post-test renal dysfunction	usually within a few days

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 15, 2026