Brain Injuries
Conditions
Keywords
traumatic, brain injury, brain regional oxygen saturation (rSO2), brain tissue oxygenation (PbtO2), cerebral perfusion pressure (CPP)
Brief summary
The purpose of this study is to investigate the relationship among regional transcranial oxygen saturation (rSO2), brain tissue oxygen pressure (PbtO2) and cerebral perfusion pressure (CPP) in patients with severe traumatic brain injury (TBI).
Detailed description
Experience with rsO2 assessed by near infrared spectroscopy (NIRS) in patients with severe TBI is lacking. Reports about the usefulness of rSO2 are contradictory as regards its technical reliability and clinical value. Continuous time-domain analysis comparing rSO2, PbtO2 and CPP has never been carried out and the correlation among these variables remains largely unknown. A significant association between rSO2 and these clinically important variables would suggest that cerebral oximetry provides relevant data signifying that rSO2 might be a useful tool assessing cerebral oxygenation in selected patients with TBI.
Interventions
DEVICEtranscranial oxygen saturation measurement (INVOS Somanetics 5100C)
rSO2 measurement
Sponsors
Hospitales Universitarios Virgen del Rocío
Study design
Observational model
CASE_CROSSOVER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Severe Traumatic Brain Injury (Glasgow Coma Scale \< 9) * Having an intraparenchymal cerebral ICP/PbtO2 catheter previously inserted. * Expected length of ICU stay \> 1 days
Exclusion criteria
* Patient's relatives refusal to patient's inclusion in the study * Patients necessitating ongoing resuscitation * End-stage in which death is imminent * Deficient signal of rSO2 impeding its proper valuation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| correlation between rSO2 and PbtO2 | four months |
Secondary
| Measure | Time frame |
|---|---|
| correlation between rSO2 and CPP | four months |
Countries
Spain
Outcome results
None listed