Studies on Aldosterone and Vascular Function

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00700479

Enrollment

Registered

2008-06-18

Start date

2006-01-31

Completion date

2008-06-30

Last updated

2008-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation

Keywords

vascular endothelium, nitric oxide, aldosterone, vascular biology

Brief summary

A randomized crossover trial to determine the effects of sodium loading and aldosterone infusion on endothelial function in normal subjects.

Interventions

DRUGaldosterone

4 hour infusion

DIETARY_SUPPLEMENTlow or high sodium diet

DRUGplacebo

placebo

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

DIAGNOSTIC

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Healthy subjects age \>18 years

Exclusion criteria

* Any chronic medical disease or chronic use of medications

Design outcomes

Primary

Measure	Time frame
Flow mediated dilation brachial artery	0 and 4 hours

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026