Acute Coronary Syndrome, Atherosclerosis, Dyslipidemia
Conditions
Brief summary
To examine effects of intensive lipid lowering therapy with atorvastatin on stabilization of coronary plaque by using optical coherence tomography (OCT) in patients with acute coronary syndrome.
Detailed description
Patients with acute coronary syndrome (myocardial infarction or unstable angina) who will undergo PCI and have at least one atherosclerotic lesion of \>25% stenosis other than culprit lesions of current ACS are enrolled. Fibrous cap thickness of a target coronary plaque is evaluated by optical coherence tomography.
Interventions
20mg/day
DRUGlow-dose atorvastatin
5mg/day
Sponsors
Wakayama Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients with acute coronary syndrome (myocardial infarction or unstable angina) who will undergo PCI. * plasma LDL cholesterol levels : \>=100mg/dL and ≤160mg/dL * at least one atherosclerotic lesion of \>25% stenosis other than culprit lesions of current ACS
Exclusion criteria
* Patients who will undergo coronary bypass surgery. * Patients with major complications during treatment of culprit coronary lesions. * Patients with an atherosclerotic lesion with \>50% stenosis at a left main trunk.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fibrous cap thickness by OCT | 12 months |
Secondary
| Measure | Time frame |
|---|---|
| macrophage number | 12 months |
Countries
Japan
Outcome results
None listed