Delirium
Conditions
Keywords
delirium, atypical antipsychotics, olanzapine, orthopedic
Brief summary
In this study we wanted to determine if perioperative administration of olanzapine prior to knee or hip replacement surgery in high risk patients would prevent the onset of postoperative delirium.
Detailed description
Postoperative delirium is a serious and common (20% to 60%) complication in orthopedic surgery patients. In this study we investigate whether prophylactic administration of olanzapine can prevent delirium from occurring after knee or hip replacement in high-risk patients \> 65 years of age. This is a randomized, double-blind, single center, placebo-controlled study.
Interventions
DRUGolanzapine
5 mg preoperative and 5mg postoperative prior to discharge to inpatient nursing floor
DRUGplacebo
placebo administered preoperatively and postoperatively prior to discharge to inpatient nursing floor
Sponsors
The New England Baptist Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* High risk for delirium age \> 65 history of delirium medical comorbidities ability to give informed consent
Exclusion criteria
* Dementia Alcohol abuse Current use of an antipsychotic Allergy to olanzapine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of delirium | days in hospital |
Secondary
| Measure | Time frame |
|---|---|
| Complications, length of stay, hospital costs | days |
Countries
United States
Outcome results
None listed