Study on Tear Proteins in Diabetic Retinopathy of Type 2 Diabetics

Tear Proteins and Diabetic Retinopathy

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00698698

Enrollment

350

Registered

2008-06-17

Start date

2009-01-31

Completion date

2011-06-30

Last updated

2009-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus

Keywords

tear proteins, diabetic retinopathy, HPLC, Mass spectroscopy

Brief summary

Diabetes mellitus is becoming a global epidemic. There is a need to devise a non invasive method for detection of diabetes and its related complication. Tear proteins are easy to collect causing no harm to a patient and different studies indicate that tear proteins of diabetic patients are significantly different from non diabetic population. This difference in the composition of tear proteins become more pronounced with advancement of diabetic retinopathy.

Detailed description

Diabetes mellitus causes a significant alteration in tear proteins. If we analyze tear proteins by means of electrophoresis, HPLC, and mass spectroscopy. We can find different type of tear proteins in different grades of diabetic retinopathy these biomarkers can help in mass screening , diagnosis and management of diabetic population.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

30 Years to 90 Years

Healthy volunteers

Yes

Inclusion criteria

* diabetic patients with type 2 diabetes * age above 30 * willing to participate

Exclusion criteria

* ocular surface disorders. * collagen vascular diseases * Limbal hyperemia * previous ocular surgery * creatinine level above 1.0 * liver diseases

Countries

Pakistan

Outcome results