Gastroesophageal Reflux Disease, Obesity
Conditions
Keywords
Gastroesophageal reflux disease, Waist circumference, Body mass index, Obesity
Brief summary
Gastroesophageal reflux disease (GERD) is a common and important disorder. Previous studies have demonstrated the association of obesity with GERD, and now obesity is regarded as a risk factor for GERD. Moreover, body mass index (BMI), an indicator of general obesity, correlates with severity of symptoms and degree of erosive esophagitis. Waist circumference, an indicator of abdominal obesity, has stronger correlation with intra-abdominal pressure and low-grade inflammatory state when compared with BMI. Nevertheless the association of waist circumference with severity of GERD has not been studied. The primary aim of this study is to compare BMI with waist circumference for their independent association with severity of GERD. The secondary aim is to evaluate independent risk factors of severity of GERD.
Detailed description
This is a cross-section observational study. Outpatients presenting with acid reflux or heart burn are interviewed with standardized questionnaire to quantify severity of symptoms. The eligible patients undergo upper endoscopy to diagnose erosive esophagitis and further classify the degree of erosions according to Los-Angels classification. Enrolled patients receive anthropometric measurements to record body weight, body height and waist circumference on the day of enrollment. Two outcomes are studied: the severity of GERD symptoms and the Los-Angels Classification of erosive esophagitis.
Interventions
All patients undergo anthropometric measurements to record body weight, body height and waist circumference on the day of enrollment
Sponsors
Lotung Poh-Ai Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* age more than 20 years old and less than 70 years old * typical gastroesophageal reflux symptoms (heart burn and acid reflux) * outpatient * complete upper gastrointestinal endoscopy
Exclusion criteria
* age less than 20 years or more than 70 years old * receive medication for reflux disease (including proton pump inhibitor, histamine type 2 receptor blocker, prokinetic agents) in previous one month * pregnant women * history of abdominal surgery * severe comorbidity with cirrhosis, end-stage renal disease, heart failure * no written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the degree fo erosive esophagitis according to Los-Angels classification | on the day of endoscopy examination |
Secondary
| Measure | Time frame |
|---|---|
| gastro-reflux severity score as evaluated by standardized questionnaire | at enrollment (before upper GI endoscopy) |
Countries
Taiwan
Outcome results
None listed