Assessment of Circulating Copeptin Levels in Healthy Subjects and Patients With Renal Insufficiency After Oral Water Load and Hypertonic Saline Infusion

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00696605

Enrollment

Registered

2008-06-12

Start date

2008-07-31

Completion date

2009-10-31

Last updated

2017-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperosmolality, Hypoosmolality, Renal Failure

Keywords

Hypoosmolality, Hyperosmolality, Copeptin, Vasopressin

Brief summary

The are 2 principal goals in this study: 1. To measure plasma copeptin levels in healthy subjects and to correlate them with plasma AVP concentrations and urine osmolalities in iso-, hypo-, and hyperosmolar states. 2. To measure plasma copeptin concentrations in patients with chronic renal failure under the same conditions described above, in order to characterize the impact of renal function on circulating copeptin levels in correlation to plasma AVP and urine osmolality.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* chronic renal failure grade I through IV * healthy age-matched controls

Exclusion criteria

* chronic renal failure grade V * heart failure * liver disease * nephrotic syndrome * anemia (hemoglobin level \< 100 g/L) * uncontrolled hypertension (systolic BP \> 160 mmHg; diastolic BP \> 95 mm Hg) * coexisting severe disease * known thyroid disease * known hypocortisolism * known hypercortisolism * known diabetes insipidus * pregnancy * lactation

Countries

Switzerland

Outcome results