Healthy Subjects
Conditions
Keywords
Benzodiazepines, Lorazepam, Diazepam, Memory, Perceptual priming, Functional brain imaging, FMRI
Brief summary
Aims : * exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI * comparing lorazepam effects to diazepam (0.3 mg/kg)effects * exploring benzodiazepines effects, after a single oral intake, on the neural correlates of successful encoding of information within explicit memory using fMRI Hypothesis : * both diazepam and lorazepam will impair explicit memory performance, but lorazepam only will impair perceptual priming * lorazepam and diazepam will modify the normal correlates of information encoding within explicit memory * lorazepam only will alter the neural correlates of perceptual priming
Interventions
DRUGDiazepam
Diazépam drug (0,3 mg/kg) on a single oral intake
DRUGLorazepam
Lorazépam drug (0,038 mg/kg) on a single oral intake
DRUGplacebo
lorazépam placebo or Diazépam placebo
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy subjects between 18 and 30 years * Students in medicine, dentistry or pharmacy * French as a mother language
Exclusion criteria
* Medical condition influencing brain function (neurological or psychiatric) * Asthma * General anesthesia in the 3 last months * Drug addiction (DSM IV criteria) * Regular medical treatment (except contraceptive pill) * Significant impairment observed during a medical examination including ECG * Intake of any psychotropic drug that can have a effect during testing * IQ (Wechsler) \< 100 * FMRI contra-indication (implantable magnetic material, claustrophobia) * Known allergy to benzodiazepine or lactose * \> 10 cigarettes/day * Pregnant or breast-feeding woman * No health insurance * Subjects who do not complete the entire study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exploring lorazepam (0.038 mg/kg) effects, after a single oral intake, in healthy volunteers, on the neural correlates of encoding and retrieval of information during a word-stem completion task (implicit memory), using fMRI | After a single oral intake |
Secondary
| Measure | Time frame |
|---|---|
| Comparing lorazepam effects to diazepam (0.3 mg/kg)effects | After a single oral intake |
| Exploring benzodiazepines effects, after a single oral intake, on the neural correlates of successful encoding of information within explicit memory using fMRI | After single oral intake |
Countries
France
Outcome results
None listed