Does Intravenous Cannabis Reduce Postoperative Nausea and Vomiting (PONV)?

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00695487

Acronym

THC

Enrollment

320

Registered

2008-06-12

Start date

2008-07-31

Completion date

2011-12-31

Last updated

2014-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea, Vomiting

Keywords

Anesthesia, THC, Postoperative Nausea

Brief summary

The investigators evaluate if intravenously applied THC (Cannabis) reduces postoperative Nausea and vomiting. THC will be given during anesthesia before emergence. We measure how long and how effective it reduces PONV

Interventions

DRUGTHC 9-d-tetra hydro cannabinol

0.125mg/kg iv one time

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* ASA I-III * elective open and laparoscopic surgery \>1hour

Exclusion criteria

* ambulatory surgery * pregnancy, breast feeding * \>ASA III * BMI \>35 * antipsychotic, antiemetic, cytostatic therapy * major cardiovascular, renal, hepatic, central nervous system disease * current chronic cannabis consumption and hard drug abuse * schizophrenia * preoperative nausea and vomiting, vestibular disease * not speaking german or french * refusal to participate

Design outcomes

Primary

Measure	Time frame
Absence of postoperative Nausea and Vomiting	0-24h after Operation

Secondary

Measure	Time frame
Psychological and physiological data after ingestion of THC Analgetics required	0-24h after operation

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026