Lactobacillus Plantarum 299v in Colon Surgery

L Plantarum 299v to Patients Undergoing Colon Resection - a Randomized Placebo-Controlled Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00695461

Acronym

Lp 299v

Enrollment

Registered

2008-06-11

Start date

2001-01-31

Completion date

2006-08-31

Last updated

2008-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacterial Translocation, Cell Proliferation, Inflammation

Keywords

Colorectal surgery, Probiotics, Lactobacillus, Bacterial translocation, Postoperative complications, Inflammatory reaction

Brief summary

Intestinal pathogenes are often involved in postoperative complications after colon surgery. Probiotic bacteria, i e live bacteria which have beneficial effects on the host when ingested, have been shown to reduce bacterial translocation in animal studies. However, in humans studies results have varied. The purpose with this study was to find whether high doses of Lactobacillus plantarum 299v affects the potentially pathogenic microflora of the gut, bacterial translocation and cell proliferation in patients undergoing planned colon surgery.

Interventions

DIETARY_SUPPLEMENTLactobacillus plantarum 299v in oatmeal drink

Bacteria in a concentration of 10(9) CFU/ml

DIETARY_SUPPLEMENTOatmeal drink

Oatmeal drink as in arm 1 but without bacteria added.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* planned resection of colon for malignant or benign disease * all ages

Exclusion criteria

* unable to understand instructions and perform preoperative intake of study preparation * rectal surgery * present or past history of endocarditis * congenital or acquired valvular heart disease

Design outcomes

Primary

Measure	Time frame
Change in intestinal bacterial microflora	Before inclusion, after treatment, during surgery, postoperative day 6, 6 weeks, 6 months

Secondary

Measure	Time frame
Bacterial translocation	During surgery
Inflammatory response (cytokines)	Preoperative, during operation, 3, 24 an 48 hours postoperastive
Cell proliferation	During surgery
Postoperative complications	One week after surgery

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026