Intrathecal Morphine in Knee Arthroplasty

Determination of the Efficacy and Side-Effect Profile of Lower Doses of Intrathecal Morphine in Patients Undergoing Total Knee Arthroplasty

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00695045

Enrollment

Registered

2008-06-11

Start date

2003-07-31

Completion date

2007-04-30

Last updated

2008-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arthroplasty, Replacement, Knee, Pain, Postoperative

Keywords

Pain, Postoperative, Arthroplasty, Replacement, Knee, Morphine, Injections, Intrathecal

Brief summary

This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement.We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Interventions

DRUGintra thecal morphine

100 mcg intrathecal morphine given once .

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients for elective total knee arthroplasty

Exclusion criteria

* No contraindication to spinal * No allergy to morphine, rescue analgesia or anti-emesis treatment.

Design outcomes

Primary

Measure	Time frame
pain	24 hours

Secondary

Measure	Time frame
nausea and vomiting	24 hours
pruritus	24 hours
sedation	24 hours

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 4, 2026