Survival Study in Patients Undergoing On-line Hemodiafiltration

A Randomized Study to Evaluate Survival in Patients Undergoing Hemodialysis or On-line Hemodiafiltration

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00694031

Acronym

ESHOL

Enrollment

906

Registered

2008-06-10

Start date

2007-05-31

Completion date

2012-01-31

Last updated

2014-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodialysis

Keywords

Mortality, Convective therapies, On-line Hemodiafiltration, Dialysis Adequacy, Age 18 or older, Undergoing hemodialysis

Brief summary

Patients on hemodialysis will be randomly assigned (1:1) to continue on conventional hemodialysis or on-line hemodiafiltration, both three times per week. A 3 year follow-up and a sample size of around 750 will be necessary to detect a 35% reduction in mortality.

Interventions

PROCEDUREHemodialysis

3 times per week

PROCEDUREOn-line hemodiafiltration

3 times per week

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age 18 and older * Currently undergoing hemodialysis * Clinical stability * Stable vascular access

Exclusion criteria

* Chronic inflammatory diseases * Liver cirrhosis * Malignancies * Chronic immunosuppressant or antiinflammatory use * Dialysis through temporary catheter or single puncture

Design outcomes

Primary

Measure	Time frame
Survival	36 months

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026