Lower Urinary Tract Symptoms, Hypertension
Conditions
Keywords
Amlodipine, Terazosin, Lower Urinary Tract Symptoms (LUTS), Essential hypertension, International Prostate Symptom Score (IPSS), Quality Of Life (QOL)
Brief summary
The aim of this study was to investigate the efficacy and safety of low dose amlodipine alone, or combined with low dose terazosin in male patients with both lower urinary tract symptoms and hypertension.
Interventions
DRUGamlodipine
amlodipine 5mg once daily for 28 days
DRUGterazosin
terazosin 2 mg once daily for 28 days
DRUGamlodipine plus terazosin
amlodipine 5 mg plus terazosin 2 mg once daily for 28days
Sponsors
The University of Science and Technology of China
Peking University First Hospital
Anhui Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Men 50 years or older 2. with LUTS \[defined as International Prostate Symptom Score (IPSS) \>= 10\]. 3. Stage 1 or 2 essential hypertension (SBP \>= 140 mm Hg and \< 180 mm Hg and/or DBP \>= 90 mm Hg and \< 110 mm Hg)
Exclusion criteria
1. A history of postural hypotension 2. Secondary hypertension 3. Prostate cancer 4. Prostate surgery or other intervention 5. Use of any agents to influence the LUTS symptoms in the last 4 weeks 6. Other severe diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary efficacy outcomes were reductions in blood pressure and International Prostate Symptoms Score (IPSS) and sub-scores. | 28th day after treatment |
Countries
China
Outcome results
None listed