Bacteremia, Bacterial Infection, Fever Without Source, Procalcitonin
Conditions
Keywords
Procalcitonin, Antibiotic, Fever without source, Fever without focus, bacteremia, Urinary tract infection
Brief summary
Serious bacterial infections are often difficult to detect in children with fever without source. Procalcitonin is a better blood marker of infection than White blood cell count and possibly than C-reactive protein. This could lead to a reduction in antibiotic prescription. Our objective is to evaluate the impact of Procalcitonin result on antibiotic prescription in children 1 to 36 month old with fever without source and our hypothesis is that it will lower the antibiotic prescription rate
Interventions
OTHERProcalcitonin dosage PCT-Q test (Brahms, Germany)
Procalcitonin result available to the attending physician
Sponsors
St. Justine's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
1 Months to 36 Months
Healthy volunteers
No
Inclusion criteria
* Children 1-36 months * With rectal temperature \>38.0 C * And no identified source of infection after history and physical examination
Exclusion criteria
* acquired or congenital immunodeficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in prescription of antibiotics between the two groups, excluding those treated for a bacterial infection identified by the ED investigations | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in hospitalization rate between the two groups (excluding those hospitalized for an identified infection) | — |
| Procalcitonin sensitivity and specificity | — |
Countries
Canada
Outcome results
None listed