Obesity
Conditions
Keywords
Obesity, Postmenopausal, Diet intervention
Brief summary
This study will compare a high-protein/low-carbohydrate diet (modified paleolithic diet, MPD) with a diet high in slow carbohydrates (Nordic Nutrition Recommendations, NNR). The diets will be compared with respect effects on weight reduction, metabolic regulation, and long-term compliance to the diet regimes. Seventy-two postmenopausal overweight healthy women have been recruited and will be followed for two years. The following variables will be studied: * Anthropometry * DEXA * OGTT * Liver fat content measured with 1H-MRS * Hepatic 11β-HSD1 activity, measured with cortisone/cortisol conversion test
Interventions
BEHAVIORALNNR (Nordic Nutrition Recommendations)
Diet with equal amounts of fat, protein and carbohydrates
BEHAVIORALMPD (Modified paleolithic diet)
A diet high in protein and fat, but low in carbohydrates
Sponsors
Umeå University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
No minimum to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Female * Postmenopausal * BMI\>28
Exclusion criteria
* Disease * Gravidity * Smoking * Prescribed medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver fat | Sept 2008 |
Secondary
| Measure | Time frame |
|---|---|
| Body weight | Sept 2008 |
| Apnea-Hypopnea Index (AHI) | Sept 2008 |
Countries
Sweden
Outcome results
None listed