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Force Enhancement of Musculus Quadriceps Femoris During and After Excentric Muscle Activity in Vivo

Force Enhancement of m. Quadriceps Femoris During and After Excentric Muscle Activity in Vivo by Maximal and Sub-maximal Deliberately Activation.

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT00690547
Enrollment
60
Registered
2008-06-04
Start date
2008-10-31
Completion date
2010-10-31
Last updated
2009-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy, Muscle Quadriceps Femoris

Keywords

Functionality, Deliberately, Activated, Quadriceps, Femoris, During, After, Active, Extension

Brief summary

Force enhancement (FE) describes the phenomenon of strength potentialization of a muscle cell or the complete muscle during and after active extension compared to the strength of an isometric contraction with same muscle length. The underlying physiological mechanism of this phenomenon is not completely known today. In vitro trials indicate that the interaction of an active and a passive component on the cellular level are responsible for the higher strength measurements. So far FE could be shown in vitro and in vivo on muscle fibers and small human muscles. Further research is needed for verification of the existence of FE in voluntary motor activity in everyday life. In order to approach this objective the investigators will scrutinize the functionality of the deliberately activated musculus (m) quadriceps femoris during and after active extension on the basis of in vivo studies.

Detailed description

The research proposal is resubmitted with no amendments made regarding content.

Interventions

OTHERmuscle activation

activation of the muscle quadriceps femoris

Sponsors

German Research Foundation
Lead SponsorOTHER

Study design

Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
MALE
Age
20 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* Males without previous muscular or neurophysiological diseases * Age between 20 and 40 years

Exclusion criteria

* Previous muscular or neurophysiological diseases

Design outcomes

Primary

MeasureTime frame
Identification of a potential Force enhancement by complex muscle activity with a high relevance for everyday life, for example more agile leg stretching (knee bend).12 months

Secondary

MeasureTime frame
Evidence of existence of the force enhancement by deliberately activated, great human muscle by sub-maximal activation12 months
Correlation between typ of muscle fiber and force enhancement in vivo12 months
Analysis of the alternation of length of the muscle fiber during and after excentric extension for the differentiated explanation of in vivo mechanism excentric and post-excentric strength12 months

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026