Antibiotics in Patients With Acute Respiratory Tract Infection With Procalcitonin as Parameter

Antibiotics in Patients With Acute Respiratory Tract Infections in Primary Care in Consideration of Procalcitonin as Additive Parameter

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00688610

Enrollment

571

Registered

2008-06-03

Start date

2007-11-30

Completion date

2008-06-30

Last updated

2009-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Tract Infection

Keywords

primary care, procalcitonin, antibiotic prescription

Brief summary

Antibiotics in patients with acute respiratory tract infections in primary care in consideration of procalcitonin as additive parameter. The purpose of this study is to compare the ordinary manner of antibiotic- prescription with the prescription in consideration of procalcitonin-value in patients with acute respiratory tract infections.

Interventions

OTHERlaboratory value procalcitonin

A. attending physician includes patient with acute respiratory infection in study, indicates antibiotic prescription and collects procalcitonin-value. Waits for decision from laboratory either change of decision or retention of decision. In case of change decision: antibiotic is not recommended, patient shall not take antibiotic. In case of retention of decision: patient may take the antibiotic. B. attending physician includes patient with acute respiratory infection in study, indicates NO antibiotic and collects procalcitonin-value. Waits for decision from laboratory either change of decision or retention of decision. In case of change decision: antibiotic is recommended, patient has to be informed about. In case of retention of decision: no change.

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 18 years or older * Informed consent * Respiratory tract infection based on the clinical judgement of the primary care physician

Exclusion criteria

* Antibiotic pretreatment in previous 14 days * Portal hypertension * Major surgeries or multiple trauma which require hospitalization, in previous 4 weeks * Autoimmune disease and systemic diseases (lupus erythematodes, wegener´s disease) * Peritoneal dialysis * Acute treated or recently operated medullary c-cell-carcinoma, SCLC, carcinoid * Other inflammatory diseases (e.g. urinary tract infection, pyelonephritis, pancreatitis

Design outcomes

Primary

Measure	Time frame
days with significant impairment due to acute respiratory tract infection	14 to 28 days after infection

Secondary

Measure	Time frame
number of antibiotic prescriptions	28 days

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026