Dengue Fever
Conditions
Keywords
Dengue fever, CLEC5A, Mannose receptor, DC-SIGN, NALP,, decoy receptor 3 (DcR3), Toll-like receptors(TLRs),, (Nod)-like receptors (NLRs)
Brief summary
The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.
Detailed description
Research has showed that CLEC5A interacts with dengue virion directly, and is responsible for dengue virus (DV)-induced DAP12 phosphorylation. Data suggests that CLEC5A is a potential therapeutic target for dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). This project will study the genes of CLEC5A, Mannose receptor, DC-SIGN, NALP, decoy receptor 3 (DcR3), Toll-like receptors(TLRs), and (Nod)-like receptors (NLRs) for both DF and DHF groups. In addition, serum level of decoy receptor 3 (DcR3) will be tested. The study will collect the blood samples from 350 healthy persons and 350 persons infected with dengue fever.
Interventions
OTHERcase/control
case: infected dengue fever people control:healthy people
Sponsors
Centers for Disease Control and Prevention
Kaohsiung Medical University Chung-Ho Memorial Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Clinical diagnosis of Dengue fever
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 檢查肝臟、腎臟及其他生化功能，並分析宿主免疫調控及血小板變化機致 | 2007/7/1 | 抽血20 c.c 檢查肝臟、腎臟及其他生化功能，並分析宿主免疫調控及血小板變化機致 |
Countries
Taiwan
Contacts
Primary ContactJih-Jin Tsai, MD
Outcome results
None listed